ArticleSchizophrenia research2018
Neural correlates of global and specific cognitive deficits in schizophrenia.
Article in Schizophrenia research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Morphometric Analysis of Structural MRI Using Schizophrenia Meta-analytic Priors Distinguish Patients from Controls in Two Independent Samples and in a Sample of Individuals With High Polygenic Risk.Schizophrenia bulletin · 2022Pooled it
- A Systematic Review of Cognition-Brain Morphology Relationships on the Schizophrenia-Bipolar Disorder Spectrum.Schizophrenia bulletin · 2021Pooled it
- Cortical Structures Underlying Schizophrenia and Sex Differences in Preadolescents: An Adolescent Brain Cognitive Development Study.Child psychiatry and human development · 2026Article
- Driving Performance in Schizophrenia: The Role of Neurocognitive Correlates-A Systematic Review.Brain sciences · 2025Review
- Mapping Multimodal Risk Factors to Mental Health Outcomes.Nature. Mental health · 2025Article
- Subgroups of cognitive impairments in schizophrenia characterized by executive function and their morphological features: a latent profile analysis study.BMC medicine · 2025Article
- Neuroimaging features of cognitive impairments in schizophrenia and major depressive disorder.Therapeutic advances in psychopharmacology · 2024Review
- Categorical and Dimensional Approaches for Psychiatric Classification and Treatment Targeting: Considerations from Psychosis Biotypes.Advances in neurobiology · 2024Review
- Disturbed Oligodendroglial Maturation Causes Cognitive Dysfunction in Schizophrenia: A New Hypothesis.Schizophrenia bulletin · 2023Article
- Repetitive Anodal TDCS to the Frontal Cortex Increases the P300 during Working Memory Processing.Brain sciences · 2022Article
- Lifespan evolution of neurocognitive impairment in schizophrenia - A narrative review.Schizophrenia research. Cognition · 2022Review
- Relationships between cognitive performance, clinical insight and regional brain volumes in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Cognitive change and antipsychotic medications: Results from a pragmatic rater-blind RCT.Schizophrenia research. Cognition · 2021Article
- Sex differences in association between cognitive impairment and clinical correlates in Chinese patients with first-episode drug-naïve schizophrenia.Annals of general psychiatry · 2021Article
- The microRNA-195 - BDNF pathway and cognitive deficits in schizophrenia patients with minimal antipsychotic medication exposure.Translational psychiatry · 2021Article
- Altered Default Mode Network Is Associated With Cognitive Impairment in CADASIL as Revealed by Multimodal NeuFrontiers in neurology · 2021Article
- Cortical Gyrification, Psychotic-Like Experiences, and Cognitive Performance in Nonclinical Subjects.Schizophrenia bulletin · 2020Article
- Neurocognitive functioning in patients with first-episode schizophrenia: results of a prospective 15-year follow-up study.European archives of psychiatry and clinical neuroscience · 2020Article
- Modulation of Slow-Wave Sleep: Implications for Psychiatry.Current psychiatry reports · 2020Review
- Prefrontal cortex eQTLs/mQTLs enriched in genetic variants associated with alcohol use disorder and other diseases.Epigenomics · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Cognitive deficits are a core feature of schizophrenia, but the neural mechanisms that contribute to these characteristics are not fully understood. This study investigated whether volume of the dorsal lateral prefrontal cortex (DLPFC), inferior frontal gyrus (IFG), hippocampus, and white matter were associated with impairment in specific cognitive domains, including executive functioning, working memory, verbal memory, verbal fluency, processing speed, versus global functioning. The multi-site data used in this study was collected from the Bipolar and Schizophrenia Network on Intermediate Phenotypes (B-SNIP), and consisted of 206 healthy controls and 247 individuals with either schizophrenia or schizoaffective disorder. The neuroimaging data was segmented based on the Destrieux atlas in FreeSurfer. Linear regression analyses revealed that global cognition, executive functioning, working memory, and processing speed were associated with all brain structures, except the DLPFC was only associated with executive fucntion. When controlling for the global cognitive deficit, executive function was trending significance with white matter, but continued to be associated with the DLPFC and IFG, as did the association between processing speed and the hippocampus. These findings suggest that volumes of the DLPFC, IFG, hippocampus, and white matter are associated with the global cognitive impairment seen in schizophrenia, but some brain structures may also be specifically related to domain-specific deficits (primarily executive function) over-and-beyond the global cognitive deficit.
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