ReviewSeminars in perinatology2018
Changing patterns of patent ductus arteriosus surgical ligation in the United States.
Review in Seminars in perinatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Patent Ductus Arteriosus and Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: A Bayesian Meta-Analysis.JAMA network open · 2023Pooled it
- Safety and Effectiveness of the KA Micro Plug for Treatment of Patent Ductus Arteriosus in Preterm Low-Birth-Weight Infants: Retrospective Analysis From a Multicenter Registry.Journal of the Society for Cardiovascular Angiography & Interventions · 2026Article
- Evaluation ofJournal of cardiovascular development and disease · 2026Article
- Article
- The impact of congenital heart disease on treatment and survival of patients with hepatoblastoma: A single-center experience.Pediatric blood & cancer · 2024Article
- Immediate Outcomes of Transcatheter Closure versus Surgical Ligation of Patent Ductus Arteriosus in Children at the Cardiac Center of Ethiopia (2012-2022): A Comparative Cross-Sectional Study.Ethiopian journal of health sciences · 2024Article
- Who Still Gets Ligated? Reasons for Persistence of Surgical Ligation of the Patent Ductus Arteriosus Following Availability of Transcatheter Device Occlusion for Premature Neonates.Journal of cardiovascular development and disease · 2024Article
- We Still Don't Know When to Close a Patent Ductus Arteriosus in Infants Born Very Premature.The Journal of pediatrics · 2024Article
- Article
- Off-label use of Lifetech KONAR-MF™ ventricular septal defect occluder for large patent ductus arteriosus closure in <6 kg infants.International journal of cardiology. Congenital heart disease · 2022Article
- Article
- Left Vocal Cord Paralysis, Lung Function and Exercise Capacity in Young Adults Born Extremely Preterm With a History of Neonatal Patent Ductus Arteriosus Surgery-A National Cohort Study.Frontiers in pediatrics · 2021Article
- Oral Versus Intravenous Medications for Treatment of Patent Ductus Arteriosus in Preterm Neonates: A Cost-Saving Initiative.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2021Article
- Patent Ductus Arteriosus of the Preterm Infant.Pediatrics · 2020Review
- PDA: Does it matter?International journal of pediatrics & adolescent medicine · 2020Article
- Late Acetaminophen Therapy for Patent Ductus Arteriosus in the Preterm Neonate.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2020Article
- Patent ductus arteriosus in preterm infants: is early transcatheter closure a paradigm shift?Journal of perinatology : official journal of the California Perinatal Association · 2019Review
- PDA clipping by video-assisted thoracoscopic surgery.Journal of thoracic disease · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Optimal management of patent ductus arteriosus (PDA) is unclear. One treatment, surgical ligation, is associated with adverse outcomes. We reviewed data from the Kids' Inpatient Database (2000-2012) to determine if PDA ligation rates: (1) changed over time, (2) varied geographically, or (3) influenced surgical complication rates. In 2012, 47,900 infants <1500g birth weight were born in the United States, including 2,800 undergoing PDA ligation (5.9%). Ligation was more likely in infants <1000g (85.9% vs. 46.2%), and associated with necrotizing enterocolitis (59.2% vs. 37.5%), BPD (54.6% vs. 15.2%), severe intraventricular hemorrhage (16.4% vs. 5.3%), and hospital transfer (37.6% vs. 16.4%). Ligation rates peaked in 2006 at 87.4 per 1000 hospital births, dropping to 58.8 in 2012, and were consistently higher in Western states. Infants undergoing ligation were more likely to experience comorbidities. Rates of ligation-associated vocal cord paralysis increased over time (1.2-3.9%); however, mortality decreased (12.4-6.5%). Thus, PDA ligation has become less frequent, although infants being ligated are smaller and more medically complex. Despite increase in some complications, mortality rates improved perhaps reflecting advances in care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.