Evidence map›Paper›PMID 29954353›Full record

SynthesisBMC pulmonary medicine2018

Effects of vitamin D supplementation on the outcomes of patients with pulmonary tuberculosis: a systematic review and meta-analysis.

Hong-Xia Wu, Xiao-Feng Xiong, Min Zhu, Jia Wei, Kai-Quan Zhuo, De-Yun Cheng

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC pulmonary medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 8 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 8 syntheses or guidelines pooled it, 88 citations in OpenAlex.

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  12. Efficacy of vitamin DThe lancet. HIV · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Hong-Xia WuDepartment of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, NO.37 Guoxue Alley, Chengdu, 610041, Sichuan, China.
Xiao-Feng XiongDepartment of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, NO.37 Guoxue Alley, Chengdu, 610041, Sichuan, China.
Min ZhuDepartment of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, NO.37 Guoxue Alley, Chengdu, 610041, Sichuan, China.
Jia WeiDepartment of Respiratory Medicine, Chengdu Second People's Hospital, Chengdu, China.
Kai-Quan ZhuoDepartment of Neurosurgery, Suining Municipal Hospital of TCM, Suining, China.
De-Yun ChengDepartment of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, NO.37 Guoxue Alley, Chengdu, 610041, Sichuan, China. chengdeyunscu@163.com.
Sichuan University · CNWest China Hospital of Sichuan University · CNChengdu Second People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D is involved in the host immune response toward Mycobacterium tuberculosis. However, the efficacy of vitamin D supplementation on sputum conversion, clinical response to treatment, adverse events, and mortality in patients with pulmonary tuberculosis (PTB) remains controversial. We aimed to clarify the efficacy and safety of vitamin D supplementation in PTB treatment.

methodsWe searched Medline, Embase, Cochrane Central Register of Controlled Trials, Web of Science for double-blind, randomized controlled trials of vitamin D supplementation in patients with PTB that reported sputum conversion, clinical response to treatment, adverse events, or mortality, published from database inception to November 26, 2017. This study was registered with PROSPERO, number CRD42018081236.

resultsA total of 1787 patients with active PTB receiving vitamin D supplementation along with standard anti-tuberculosis regimen were included in the eight trials with different doses of vitamin D ranging from 1000 IU/day to 600,000 IU/month at different intervals. Primary analysis revealed that vitamin D supplementation increased the proportion of sputum smear and culture conversions (OR 1.21, 95%CI 1.05~ 1.39, z = 2.69, P = 0.007; OR 1.22, 95%CI 1.04~ 1.43, z = 2.41, P = 0.02), but did not improve the time to sputum smear and culture conversions (HR 1.07, 95%CI 0.83~ 1.37, z = 0.50, P = 0.62; HR 0.97, 95%CI 0.76~ 1.23, z = 0.29, P = 0.77). In the secondary analysis, vitamin D improved serum 25(OH)D, plasma calcium concentration, lymphocyte count, and chest radiograph (MD 103.36, 95%CI 84.20~ 122.53, z = 10.57, P < 0.00001; SMD 0.26, 95%CI 0.15~ 0.37, z = 4.61, P < 0.00001; MD 0.09, 95%CI 0.03~ 0.14, z = 2.94, P = 0.003); MD -0.33, 95% CI -0.57~ - 0.08 z = 2.57, P = 0.01), but had no impact on adverse events, mortality and other indicators(TB score, BMI, mean mid-upper arm circumference, weight gain, CRP, ESR, and other blood cells) (P > 0.05).

conclusionsVitamin D supplementation can be considered as a combination therapy in patients with PTB.

Indexed as

Dietary SupplementsAntitubercular AgentsHumansMycobacterium tuberculosisSputumTreatment OutcomeTuberculosis, PulmonaryVitamin DAntitubercular AgentsVitamin DMeta-analysisTherapyTuberculosisVitamin D

Identifiers

PMID29954353
PMCPMC6025740
OpenAlexW2811128385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.