ArticleBMC cardiovascular disorders2018
Numerical analysis of the impact of flow rate, heart rate, vessel geometry, and degree of stenosis on coronary hemodynamic indices.
Article in BMC cardiovascular disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 82 citations in OpenAlex.
- Parent Artery Disease-Related Stroke: What Is the Impact on Endovascular Treatment? A Narrative Review.Journal of clinical medicine · 2026Review
- Fluid-Structure Interaction Analysis of Hyoid Bone-Induced Compression on Carotid Artery Hemodynamics.Biomedical engineering and computational biology · 2026Article
- Establishing Hemodynamic Convergence Framework for Coronary Digital Twins Under Realistic Dynamic Heart Rates.Physics of fluids (Woodbury, N.Y. : 1994) · 2025Article
- Hemodynamic effects of stenosis with varying severity in different segments of the carotid artery using computational fluid dynamics.Scientific reports · 2025Article
- Narrowings of the Deep Cerebral Perforating Arteries Ostia: Geometry, Structure, and Clinical Implications.Journal of stroke · 2025Article
- Article
- Non-invasive fractional flow reserve estimation in coronary arteries using angiographic images.Scientific reports · 2024Article
- The Stress Phase Angle Measurement Using Spectral Domain Optical Coherence Tomography.Sensors (Basel, Switzerland) · 2023Article
- The Comparative Method Based on Coronary Computed Tomography Angiography for Assessing the Hemodynamic Significance of Coronary Artery Stenosis.Cardiovascular engineering and technology · 2023Article
- Machine Learning Identification Framework of Hemodynamics of Blood Flow in Patient-Specific Coronary Arteries with Abnormality.Journal of cardiovascular translational research · 2023Article
- Time-resolved simulation of blood flow through left anterior descending coronary artery: effect of varying extent of stenosis on hemodynamics.BMC cardiovascular disorders · 2023Article
- Multivariable Technique for the Evaluation of the Trans-stenotic Pressure Gradient.Cardiovascular engineering and technology · 2023Article
- Non-invasive diagnostics of blockage growth in the descending aorta-computational approach.Medical & biological engineering & computing · 2022Article
- Engineering nano-drug biointerface to overcome biological barriers toward precision drug delivery.Journal of nanobiotechnology · 2022Review
- Fractional Flow Reserve (FFR) Estimation from OCT-Based CFD Simulations: Role of Side Branches.Applied sciences (Basel, Switzerland) · 2022Article
- Hemodynamic Characteristics of Patients With Suspected Coronary Heart Disease at Their Initial Visit.Frontiers in physiology · 2021Article
- Study of Coronary Atherosclerosis Using Blood Residence Time.Frontiers in physiology · 2021Article
- Feasibility of evaluating the stenosis of intracranial segment in the vertebral artery using neck-brain integrated ultrasound: a comparison with computed tomography angiography and digital subtraction angiography.Annals of translational medicine · 2020Article
- Geometric determinants of local hemodynamics in severe carotid artery stenosis.Computers in biology and medicine · 2019Article
- The Role of Midkine in Arteriogenesis, Involving Mechanosensing, Endothelial Cell Proliferation, and Vasodilation.International journal of molecular sciences · 2018Review
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe stenosis of the coronary arteries is usually caused by atherosclerosis. Hemodynamic significance of patient-specific coronary stenoses and the risk of its progression may be assessed by comparing the hemodynamic effects induced by flow disorders. The present study shows how stenosis degree and variable flow conditions in coronary artery affect the oscillating shear index, residence time index, pressure drop coefficient and fractional flow reserve. We assume that changes in the hemodynamic indices in relation to variable flow conditions and geometries evaluated using the computational fluid dynamics may be an additional factor for a non-invasive assessment of the coronary stenosis detected on multi-slice computed tomography.
methodsThe local-parametrised models of basic shapes of the vessels, such as straight section, bend, and bifurcation as well as the global-patient-specific models of left coronary artery were used for numerical simulation of flow in virtually reconstructed stenotic vessels. Calculations were carried out for vessels both without stenosis, and vessels of 10 to 95% stenosis. The flow rate varied within the range of 20 to 1000 ml/min, and heart rate frequency within the range of 30 to 210 cycles/min. The computational fluid dynamics based on the finite elements method verified by the experimental measurements of the velocity profiles was used to analyse blood flow in the coronary arteries.
resultsThe results confirm our preliminary assumptions. There is significant variation in the coronary hemodynamic indices value caused by disturbed flow through stenosis in relation to variable flow conditions and geometry of vessels.
conclusionVariations of selected hemodynamic indexes induced by change of flow rate, heart rate and vessel geometry, obtained during a non-invasive study, may assist in evaluating the risk of stenosis progression and in carrying out the assessment of the hemodynamic significance of coronary stenosis. However, for a more accurate assessment of the variability of indices and coronary stenosis severity both local (near the narrowing) and global (in side branches) studies should be used.
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