Evidence map›Paper›PMID 29953989›Full record

ArticleNeuroepidemiology2018

Regional Subclinical Cerebrovascular Disease Is Associated with Balance in an Elderly Multi-Ethnic Population.

Joshua Z Willey, Yeseon P Moon, Mandip S Dhamoon, Erin R Kulick, Ahmet Bagci, Noam Alperin, Ying Kuen Cheung, Clinton B Wright, Ralph L Sacco, Mitchell S V Elkind

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroepidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Joshua Z WilleyDepartment of Neurology, Columbia University, New York, New York, USA.
Yeseon P MoonDepartment of Neurology, Columbia University, New York, New York, USA.
Mandip S DhamoonDepartment of Neurology, Mount Sinai School of Medicine, New York, New York, USA.
Erin R KulickDepartment of Epidemiology, Columbia University, New York, New York, USA.
Ahmet BagciEvelyn McKnight Brain Institute, University of Miami, Miami, Florida, USA.
Noam AlperinEvelyn McKnight Brain Institute, University of Miami, Miami, Florida, USA.
Ying Kuen CheungDepartment of Biostatistics, Columbia University, New York, New York, USA.
Clinton B WrightNational Institutes of Health, NINDS, Bethesda, Maryland, USA.
Ralph L SaccoEvelyn McKnight Brain Institute, University of Miami, Miami, Florida, USA.
Mitchell S V ElkindDepartment of Neurology, Columbia University, New York, New York, USA.
Columbia University · USUniversity of Miami · USIcahn School of Medicine at Mount Sinai · USNational Institutes of Health · US

Funding

STROKE INCIDENCE AND RISK FACTORS IN A TRI-ETHNIC REGIONR01NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 1993 to 2019
$19.2M
Brown Respiratory Research Training ProgramT32HL134625 · NHLBI · BROWN UNIVERSITY · PI Elizabeth O Harrington, Sharon Irene Smith Rounds · 2017 to 2026
$5.1M
Neuro-vascular Disease as a Cause of Impaired MobilityK23NS073104 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WILLEY, JOSHUA ZEBADIAH · 2011 to 2015
$940k
NINDS NIH HHS K23 NS073104NINDS NIH HHS R01 NS029993
6 · The paper itself

Abstract

introductionWhite matter hyperintensity volume (WMHV) and subclinical brain infarcts (SBI) are associated with impaired mobility, but less is known about the association of WMHV in specific brain regions. We hypothesized that anterior WMHV would be associated with lower scores on the Short Physical Performance Battery (SPPB), a well-validated mobility scale.

methodsThe SPPB was measured a median of 5 years after enrollment into the Northern Manhattan MRI sub study. Volumetric distributions for WMHV in 14 brain regions as a proportion of total cranial volume were determined. Multi-variable linear regression was performed to examine the association of SBI and regional log-WMHV with the SPPB score.

resultsAmong 668 participants with SPPB measurements (mean 74 ± 9 years, 37% male and 70% Hispanic), the mean SPPB score was 8.2 ± 2.9. Total (beta = -0.3 per SD, p = 0.001), anterior periventricular (beta = -0.4 per SD, p = 0.001), parietal (beta = -0.2 per SD, p = 0.02) and frontal (beta = -0.3 per SD, p = 0.002) WMHVs were associated with SPPB; other WMHV and SBI were not associated with the SPPB.

conclusionsWMHV, especially in the anterior -cerebral regions, is associated with a lower SPPB. Prevention of subclinical cerebrovascular disease is a potential target to prevent physical decline in the elderly.

Indexed as

AgedAged, 80 and overBrainCerebrovascular DisordersFemaleHumansMagnetic Resonance ImagingMalePostural BalanceProspective StudiesSeverity of Illness IndexWhite MatterBalanceMagnetic resonance imagingWhite matter hyperintensities

Identifiers

PMID29953989
PMCPMC6093792
OpenAlexW2810423219

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.