Evidence map›Paper›PMID 29953616›Full record

ArticleEuropean journal of immunology2018

Sca-1

Guobao Chen, William Bracamonte-Baran, Nicola L Diny, Xuezhou Hou, Monica V Talor, Kai Fu, Yue Liu, Giovanni Davogustto, Hernan Vasquez, Heinrich Taegtmeyer and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Myocardial Immune Cells: The Basis of Cardiac Immunology.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Fibroblast-Mediated Macrophage Recruitment Supports Acute Wound Healing.The Journal of investigative dermatology · 2025
    Article
  9. PdgfrαGenes & diseases · 2025
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Multilineage contribution of CD34Basic research in cardiology · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Age and sex dependency of thoracic aortopathy in a mouse model of Marfan syndrome.American journal of physiology. Heart and circulatory physiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Guobao ChenDepartment of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
William Bracamonte-BaranDepartment of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Nicola L DinyW. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Xuezhou HouW. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Monica V TalorDepartment of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Kai FuDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Yue LiuDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Giovanni DavogusttoDepartment of Internal Medicine, Division of Cardiology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
Hernan VasquezDepartment of Internal Medicine, Division of Cardiology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
Heinrich TaegtmeyerDepartment of Internal Medicine, Division of Cardiology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
O Howard FrazierTexas Heart Institute, CHI St. Luke's Health - Baylor St. Luke's Medical Center, MC 2-114A, PO Box 20345, Houston, TX, USA.
Ari WaismanInstitute for Molecular Medicine, University of Mainz, Mainz, Germany.
Simon J ConwayWells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.
Fengyi WanDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Daniela ČihákováDepartment of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Johns Hopkins University · USThe University of Texas Health Science Center at Houston · USIndiana University – Purdue University Indianapolis · USInstitute of Molecular Biology · DEJohns Hopkins Medicine · USSt. Luke's Hospital · USThe University of Texas Health Science Center · US

Funding

SWITCHING OF METABOLIC GENES IN UNLOADED HEARTR01HL061483 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TAEGTMEYER, HEINRICH · 1999 to 2021
$6.2M
Myeloid Cells are Critical in Inflammatory Heart DiseaseR01HL118183 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CIHAKOVA, DANIELA · 2014 to 2023
$4.4M
PARylation in genotoxic stress-induced NF-kB activation Supplement for Research on Sex/Gender InfluencesR01GM111682 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI WAN, FENGYI · 2015 to 2019
$2.0M
Mechanisms of cardiac and pulmonary fibrosis in relation to TGF-beta signaling and miR-145 functionR01HL135657 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI CONWAY, SIMON JAMES, LILLY, BRENDA J · 2017 to 2020
$1.7M
Role of Sca-1+Cardiac Fibroblasts in Inflammatory Heart Disease`R01HL136586 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CIHAKOVA, DANIELA · 2018 to 2021
$1.6M
Eosinophilic MyocarditisR01HL113008 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CIHAKOVA, DANIELA · 2012 to 2015
$1.6M
NHLBI NIH HHS R01 HL061483NHLBI NIH HHS R01 HL113008NHLBI NIH HHS R01 HL118183NHLBI NIH HHS R01HL118183NHLBI NIH HHS R01 HL135657NHLBI NIH HHS R01 HL136586NHLBI NIH HHS R01HL136586NIGMS NIH HHS R01 GM111682NIGMS NIH HHS R01GM111682
6 · The paper itself

Abstract

The causative effect of GM-CSF produced by cardiac fibroblasts to development of heart failure has not been shown. We identified the pathological GM-CSF-producing cardiac fibroblast subset and the specific deletion of IL-17A signaling to these cells attenuated cardiac inflammation and heart failure. We describe here the CD45

Indexed as

AnimalsAtaxin-1Cells, CulturedChemokine CCL2FibroblastsGranulocyte-Macrophage Colony-Stimulating FactorHeart FailureHumansInterleukin-17MiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutMyocardial InfarctionMyocarditisMyocytes, CardiacAtaxin-1Atxn1 protein, mouseCCL2 protein, humanChemokine CCL2Granulocyte-Macrophage Colony-Stimulating FactorIl17a protein, mouseInterleukin-17FibroblastsGM-CSFHeart failureIL-17Myocarditis

Identifiers

PMID29953616
PMCPMC6696927
OpenAlexW2811050705

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.