Trial reportPloS one2018
Quantitative analysis of optical coherence tomographic angiography (OCT-A) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) corresponds to visual function.
Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Optical Coherence Tomography Angiography Assessment of the Peripapillary Vessel Density and Structure in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy: A Meta-Analysis.BioMed research international · 2020Pooled it
- Resolution of disc oedema in nonarteritic anterior ischaemic optic neuropathy versus optic neuritis: a retrospective, cross-sectional study.BMC ophthalmology · 2026Article
- A case-control study of peripapillary microvascular structure by OCT-angiography in non-arteritic ischaemic optic neuropathy at early and resolutive stages.Eye (London, England) · 2025Article
- Article
- Structural-Functional Correlation in Non-Arteritic Acute Ischemic Optic Neuropathy.Eye and brain · 2025Article
- Benefit of Optical Coherence Tomography-Angiography in Patients Undergoing Transsphenoidal Pituitary Adenoma Surgery: A Prospective Controlled Study.Diagnostics (Basel, Switzerland) · 2024Article
- Differential Capillary and Large Vessel Analysis Improves OCTA Classification of Diabetic Retinopathy.Investigative ophthalmology & visual science · 2024Article
- Differential artery-vein analysis improves the OCTA classification of diabetic retinopathy.Biomedical optics express · 2024Article
- Impact of Lipid Parameters on Visual Acuity Change in Non-Arteritic Anterior Ischemic Optic Neuropathy.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- Optical coherence tomography angiography findings in patients affected by giant cell arteritis, with and without ocular involvement: a pilot study.Frontiers in medicine · 2024Article
- Vascular Changes in the Macula of Patients after Previous Episodes of Vision Loss Due to Leber Hereditary Optic Neuropathy and Non-Arteritic Ischemic Optic Neuropathy.Diagnostics (Basel, Switzerland) · 2023Article
- An open-source deep learning network AVA-Net for arterial-venous area segmentation in optical coherence tomography angiography.Communications medicine · 2023Article
- The correlation between non-arteritic anterior ischemic optic neuropathy and cerebral infarction.Translational neuroscience · 2023Article
- Idiopathic Intracranial Hypertension Papillopathy due to Hormonal Changes during Pregnancy.Case reports in ophthalmological medicine · 2023Article
- Ischemic Optic Neuropathies: Current Concepts.Annals of Indian Academy of Neurology · 2022Article
- MF-AV-Net: an open-source deep learning network with multimodal fusion options for artery-vein segmentation in OCT angiography.Biomedical optics express · 2022Article
- Macular Blood Flow and Pattern Electroretinogram in Normal Tension Glaucoma.Journal of clinical medicine · 2022Article
- Evaluation of Optic Disc Perfusion with Optical Coherence Tomography Angiography in Acute Non-arteritic Anterior Ischemic Optic NeuropathyTurkish journal of ophthalmology · 2022Article
- The Value of Optical Coherence Tomography Angiography (OCT-A) in Neurological Diseases.Diagnostics (Basel, Switzerland) · 2022Review
- Peripapillary and macular microvasculature features of non-arteritic anterior ischemic optic neuropathy.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNon-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of non-glaucomatous optic neuropathy in older adults. Optical coherence tomographic angiography (OCT-A) is an emerging, non-invasive method to study the microvasculature of the posterior pole, including the optic nerve head. The goal of this study was to assess the vascular changes in the optic nerve head and peripapillary area associated with NAION using OCT-A.
designRetrospective comparative case series.
methodsWe performed OCT-A in 25 eyes (7 acute and 18 non-acute) in 19 patients with NAION. Fellow, unaffected eyes were analyzed for comparison. Patent macro- and microvascular densities were quantified in the papillary and peripapillary regions of unaffected, acutely affected, and non-acutely affected eyes and compared across these groups according to laminar segment and capillary sampling region, and with respect to performance on automated visual field testing.
resultsIn acutely affected eyes, OCT-A revealed a reduction in the signal from the major retinal vessels and dilation of patent superficial capillaries in the peripapillary area. By contrast, non-acutely affected eyes showed attenuation of patent capillaries. The peripapillary choriocapillaris was obscured by edema in acute cases, but was similar between non-acute and unaffected eyes. The degree of dilation of the superficial microvasculature in the acute phase and attenuation in the non-acute phase each correlated inversely with visual field performance. The region of reduced patent capillary density correlated with the location of visual field defects in 80% of acute cases and 80% of non-acute cases.
conclusionsOCT-A reveals a dynamic shift in the superficial capillary network of the optic nerve head with strong functional correlates in both the acute and non-acute phases of NAION. Further study may validate OCT-A as a useful adjunctive diagnostic tool in the evaluation of ischemic optic neuropathy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.