Evidence map›Paper›PMID 29953253›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2018

Lipid malabsorption from altered hormonal signaling changes early gut microbial responses.

Natalie A Terry, Lucie V Ngaba, Benjamin J Wilkins, Danielle Pi, Nishi Gheewala, Klaus H Kaestner

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Crosstalk between the growth hormone/insulin-like growth factor-1 axis and the gut microbiome: A new frontier for microbial endocrinology.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Natalie A TerryDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia , Philadelphia, Pennsylvania.ORCID 0000-0003-2570-6176
Lucie V NgabaDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia , Philadelphia, Pennsylvania.
Benjamin J WilkinsPerelman School of Medicine at the University of Pennsylvania , Philadelphia, Pennsylvania.
Danielle PiDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia , Philadelphia, Pennsylvania.
Nishi GheewalaDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia , Philadelphia, Pennsylvania.
Klaus H KaestnerPerelman School of Medicine at the University of Pennsylvania , Philadelphia, Pennsylvania.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

TRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI JONATHAN P KATZ · 1997 to 2026
$32.5M
REGULATORY CASCADES IN GASTROINTESTINAL PROLIFERATIONR01DK053839 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI KAESTNER, KLAUS H · 1998 to 2011
$4.5M
Regulatory cascades in gastrointestinal proliferationR37DK053839 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI KAESTNER, KLAUS H · 2012 to 2021
$3.8M
Role of Cirhin/Utp4 in biliary development and diseaseK08DK099379 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI WILKINS, BENJAMIN J · 2014 to 2018
$737k
ROLE OF INTESTINAL ARX IN ENTEROENDOCRINE DEVELOPMENT AND CONGENITAL DIARRHEAK08DK105354 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI TERRY, NATALIE A · 2015 to 2017
$460k
NIDDK NIH HHS K08 DK099379NIDDK NIH HHS K08 DK105354NIDDK NIH HHS P30 DK050306NIDDK NIH HHS R01 DK053839NIDDK NIH HHS R37 DK053839
6 · The paper itself

Abstract

Infants with congenital diarrheal disorders caused by enteroendocrine cell dysgenesis, or the loss of intestinal endocrine cells, causes severe malabsorptive diarrhea, though the mechanism is not fully understood. The transcription factor "aristaless-related homeobox" (Arx) is specifically expressed in intestinal endocrine cells. This study seeks to characterize the early malabsorptive phenotype of mice deficient for Arx using cell-type specific gene ablation in Villin-Cre; Arx

Indexed as

Gastrointestinal MicrobiomeAnimalsCell DifferentiationCell LineageDiarrheaEnterocytesEnteroendocrine CellsGastrointestinal HormonesHomeodomain ProteinsIntestine, SmallMalabsorption SyndromesMiceMice, Inbred C57BLPancreatitis-Associated ProteinsPaneth CellsSignal TransductionARX protein, mouseGastrointestinal HormonesHomeodomain ProteinsPancreatitis-Associated ProteinsReg3b protein, mouseTranscription FactorsArxcongenital diarrheaenteroendocrineReg3β

Identifiers

PMID29953253
PMCPMC6230693
OpenAlexW2810919658

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.