Evidence map›Paper›PMID 29952786›Full record

SynthesisAIDS (London, England)2018

Noncommunicable diseases among HIV-infected persons in low-income and middle-income countries: a systematic review and meta-analysis.

Pragna Patel, Charles E Rose, Pamela Y Collins, Bernardo Nuche-Berenguer, Vikrant V Sahasrabuddhe, Emmanuel Peprah, Susan Vorkoper, Sonak D Pastakia, Dianne Rausch, Naomi S Levitt and 1 more

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in AIDS (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 180 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
180citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

180 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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120 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pragna PatelCenter for Global Health.
Charles E RoseNational Center on Birth Defects & Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia.
Pamela Y CollinsUniversity of Washington, Department of Psychiatry and Behavioral Sciences and Department of Global Health.
Bernardo Nuche-BerenguerNational Institute of Diabetes and Digestive and Kidney Diseases.
Vikrant V SahasrabuddheNational Cancer Institute.
Emmanuel PeprahNational Heart, Lung, and Blood Institute.
Susan VorkoperFogarty International Center, National Institutes of Health, Bethesda, Maryland.
Sonak D PastakiaPurdue University College of Pharmacy, West Lafayette, Indiana, USA.
Dianne RauschNational Institute of Mental Health, National Institutes of Health.
Naomi S LevittDepartment of Medicine, University of Cape Town, Cape Town, South Africa.
NIH HIV/NCD Project Disease Condition Technical Operating Group

Funding

Intramural NIH HHS Z99 TW999999
6 · The paper itself

Abstract

objectiveTo appropriately identify and treat noncommunicable diseases (NCDs) among persons living with HIV (PLHIV) in low-and-middle-income countries (LMICs), it is imperative to understand the burden of NCDs among PLHIV in LMICs and the current management of the diseases.

designSystematic review and meta-analysis.

methodsWe examined peer-reviewed literature published between 1 January 2010 and 31 December 2016 to assess currently available evidence regarding HIV and four selected NCDs (cardiovascular disease, cervical cancer, depression, and diabetes) in LMICs with a focus on sub-Saharan Africa. The databases, PubMed/MEDLINE, Cochrane Review, and Scopus, were searched to identify relevant literature. For conditions with adequate data available, pooled estimates for prevalence were generated using random fixed effects models.

resultsSix thousand one hundred and forty-three abstracts were reviewed, 377 had potentially relevant prevalence data and 141 were included in the summary; 57 were selected for quantitative analysis. Pooled estimates for NCD prevalence were hypertension 21.2% (95% CI 16.3-27.1), hypercholesterolemia 22.2% (95% CI 14.7-32.1), elevated low-density lipoprotein 23.2% (95% CI 15.2-33.6), hypertriglyceridemia 27.2% (95% CI 20.7-34.8), low high-density lipoprotein 52.3% (95% CI 35.6-62.8), obesity 7.8% (95% CI 4.3-13.9), and depression 24.4% (95% CI 12.5-42.1). Invasive cervical cancer and diabetes prevalence were 1.3-1.7 and 1.3-18%, respectively. Few NCD-HIV integrated programs with screening and management approaches that are contextually appropriate for resource-limited settings exist.

conclusionImproved data collection and surveillance of NCDs among PLHIV in LMICs are necessary to inform integrated HIV/NCD care models. Although efforts to integrate care exist, further research is needed to optimize the efficacy of these programs.

Indexed as

AdultAfrica South of the SaharaAgedAged, 80 and overCardiovascular DiseasesDepressionDeveloping CountriesDiabetes MellitusFemaleHIV InfectionsHumansMaleMiddle AgedPrevalenceUterine Cervical Neoplasms

Identifiers

PMID29952786
PMCPMC6380891

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.