Evidence map›Paper›PMID 29952657›Full record

ArticleDento maxillo facial radiology2019

Medication related osteonecrosis of the jaw in osteoporotic

Kaycee Walton, Tristan R Grogan, Edwin Eshaghzadeh, Danny Hadaya, David A Elashoff, Tara L Aghaloo, Sotirios Tetradis

Abstract read
In one paragraph

Article in Dento maxillo facial radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

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  11. Comparison of non-medication-related osteonecrosis and medication-related osteonecrosis of the jaw: a pilot study.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kaycee WaltonDivision of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, USA.
Tristan R GroganDepartment of Medicine Statistics, Core David Geffen School of Medicine, Los Angeles, CA, USA.
Edwin EshaghzadehDivision of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, USA.
Danny HadayaDivision of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, USA.
David A ElashoffDepartment of Medicine Statistics, Core David Geffen School of Medicine, Los Angeles, CA, USA.
Tara L AghalooDivision of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, USA.
Sotirios TetradisDivision of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, USA.

Funding

Pathophysiologic Mechanisms of Bisphosphonate Related Osteonecrosis of the JawsR01DE019465 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TETRADIS, SOTIRIOS · 2009 to 2024
$5.4M
NIDCR NIH HHS R01 DE019465
6 · The paper itself

Abstract

objectivesTo explore whether differences exist in the clinical and radiographic presentation of oncologic

methodsWe retrospectively assessed panoramic radiographs and CBCT examinations of 70 MRONJ patients receiving antiresorptive medications for the management of either osteoporosis or bone malignancy. Radiographic features of MRONJ were documented and categorized according to severity. A composite radiographic index (CRI) was constructed to account for the heterogeneity in radiographic manifestations of MRONJ and further stratify extent of osseous changes.

resultsPatients with osteoporosis were mostly older females and presented more frequently with Stage 2 MRONJ, while patients with malignancy were equally distributed between males and females, and presented mostly with Stage 1 MRONJ. Most MRONJ lesions in oncologic patients occurred in the mandible, whereas the maxilla and mandible were equally affected in osteoporotic patients. Patients with minimal radiographic changes (low CRI score) often presented with MRONJ in dentate areas, while most patients in medium and high CRI groups presented with MRONJ after recent tooth extraction. The low CRI group consisted of primarily oncologic patients, while osteoporotic

conclusionsOur data identify differences in the MRONJ appearance of patients with osteoporosis

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawBone Density Conservation AgentsOsteoporosisFemaleHumansMaleRetrospective StudiesTooth ExtractionBone Density Conservation Agents

Identifiers

PMID29952657
PMCPMC6398905

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.