ReviewAnesthesia progress2018
True Allergy to Amide Local Anesthetics: A Review and Case Presentation.
Review in Anesthesia progress, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Decision-making regarding dental treatments - What factors matter from patients' perspective? A systematic review.BMC oral health · 2025Pooled it
- A meta-analysis on the efficacy of the ropivacaine infiltration in comparison with other dental anesthetics.Clinical oral investigations · 2021Pooled it
- A protocol proposal for safe dental anaesthesia in paediatric patients with allergic backgrounds: insights from a case series of allergic patients.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Acute respiratory distress syndrome after administration of lidocaine in bronchoscopy.Lung India : official organ of Indian Chest Society · 2026Article
- Chronic magnesium supplementation in a patient with relapsing severe hypomagnesaemia due to a novelBMJ case reports · 2026Article
- Common and Uncommon Complications of Chest Port Implantation.Current oncology reports · 2025Review
- True Allergies to Articaine: A 25-Year Analysis.Dentistry journal · 2025Review
- Article
- Diagnosis and Treatment of Perioperative Allergic Complications: A Practical Review.Plastic and reconstructive surgery. Global open · 2024Review
- Development and Validation of the SCAN-Score to Indicate General Anesthesia for Dental Care in Children.Journal of clinical medicine · 2024Article
- Intraoperative Hemostasis Using WALANT Versus Tourniquet; A Focused Review on Carpal Tunnel Syndrome and Trigger Finger Release.World journal of plastic surgery · 2024Review
- Review
- Review
- A case report of effective intra-articular elcatonin administration in a patient with osteonecrosis of the lunate.International journal of surgery case reports · 2023Article
- Allergy to Local Anesthetics is a Rarity: Review of Diagnostics and Strategies for Clinical Management.Clinical reviews in allergy & immunology · 2023Review
- Best practices for interventional pain procedures in the setting of a local anesthetic shortage: A practice advisory from the Spine Intervention Society.Interventional pain medicine · 2023Article
- Current Evidence Involving WALANT Surgery.Journal of hand surgery global online · 2022Review
- Local Anesthesia in Interventional Radiology.Seminars in interventional radiology · 2022Review
- Interventional Radiology Regional Anesthesia Approaches for Intra- and Postprocedural Pain Control.Seminars in interventional radiology · 2022Review
- Adverse effects following dental local anesthesia: a literature review.Journal of dental anesthesia and pain medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adverse reactions to local anesthetics are usually a reaction to epinephrine, vasovagal syncope, or overdose toxicity. Allergic reactions to local anesthetics are often attributed to additives such as metabisulfite or methylparaben. True allergic reactions to amide local anesthetics are extremely rare but have been documented. Patients with true allergy to amide local anesthetics present a challenge to the dental practitioner in providing adequate care with appropriate intraoperative pain management. Often, these patients may be treated under general anesthesia. We report a case of a 43-year-old female patient that presented to NYU Lutheran Medical Center Dental Clinic with a documented history of allergy to amide local anesthetics. This case report reviews the use of 1% diphenhydramine with 1:100,000 epinephrine as an alternative local anesthetic and reviews the relevant literature.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.