ArticleBehavioral neuroscience2018
Timing of cyclic estradiol treatment differentially affects cognition in aged female rhesus monkeys.
Article in Behavioral neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex.Nature communications · 2022Pooled it
- Article
- Evolutionary Convergence of the Arcuate Fasciculus in Marmosets and Humans.bioRxiv : the preprint server for biology · 2025Article
- Article
- The aged female rhesus macaque as a translational model for human menopause and hormone therapy.Hormones and behavior · 2024Article
- Genetic context drives age-related disparities in synaptic maintenance and structure across cortical and hippocampal neuronal circuits.Aging cell · 2024Article
- Modulation of neural gene networks by estradiol in old rhesus macaque females.bioRxiv : the preprint server for biology · 2023Article
- Effects of estradiol supplementation on the brain transcriptome of old rhesus macaques maintained on an obesogenic diet.GeroScience · 2022Article
- Early Alzheimer's disease-like reductions in gray matter and cognitive function with aging in nonhuman primates.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Aging-related Alzheimer's disease-like neuropathology and functional decline in captive vervet monkeys (Chlorocebus aethiops sabaeus).American journal of primatology · 2021Review
- Previous estradiol treatment during midlife maintains transcriptional regulation of memory-related proteins by ERα in the hippocampus in a rat model of menopause.Neurobiology of aging · 2021Article
- Estrogen receptor α: a critical role in successful female cognitive aging.Climacteric : the journal of the International Menopause Society · 2021Article
- Shaping brain structure: Genetic and phylogenetic axes of macroscale organization of cortical thickness.Science advances · 2020Article
- Estradiol Replacement at the Critical Period Protects Hippocampal Neural Stem Cells to Improve Cognition in APP/PS1 Mice.Frontiers in aging neuroscience · 2020Article
- The Critical Period for Neuroprotection by Estrogen Replacement Therapy and the Potential Underlying Mechanisms.Current neuropharmacology · 2020Review
- Estradiol treatment improves biological rhythms in a preclinical rat model of menopause.Neurobiology of aging · 2019Article
- Interest in non-social novel stimuli as a function of age in rhesus monkeys.Royal Society open science · 2019Article
- A heartfelt message, estrogen replacement therapy: use it or lose it.American journal of physiology. Heart and circulatory physiology · 2018Review
- Estrogens, Aging, and Working Memory.Current psychiatry reports · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Some evidence suggests that there may be a limited "window of opportunity" for beneficial effects of hormone therapy after menopause in women. We tested whether the timing of cyclic estradiol (E2) treatment impacted its effect on cognitive function in aged, surgically menopausal (ovariectomized) rhesus monkeys. Monkeys were assigned to one of four treatment conditions after ovariectomy: either vehicle or E2 treatment for the duration of the protocol, vehicle for the first 2 years of the protocol followed by E2 for the remainder (delayed treatment), or E2 for the first 11 months of the protocol followed by vehicle for the remainder (withdrawn treatment). Delayed treatment addressed the hypothesis that E2 treatment initiated more than 2 years postovariectomy would have a reduced effect on cognitive function. Withdrawn treatment mirrored current clinical advice to women to use hormone therapy in the initial postmenopausal period then discontinue it. Two periods of cognitive testing assessed treatment effects on cognition over time. E2 treatment predominantly affected a prefrontal cortex-dependent test of spatiotemporal working memory (delayed response). Monkeys with delayed E2 treatment modestly improved in delayed response performance over time, whereas vehicle-treated monkeys declined. Monkeys with withdrawn E2 treatment maintained their performance across assessments, as did monkeys treated with E2 across the entire protocol. These findings suggest that a "window of opportunity" for hormone treatment after cessation of ovarian function, if present in nonhuman primates, lasts longer than 2 years. They also support the notion that beneficial effects of hormone therapy may persist after discontinuation of treatment. (PsycINFO Database Record
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.