Evidence map›Paper›PMID 29952221›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2018

Iloprost attenuates hyperoxia-mediated impairment of lung development in newborn mice.

Nelida Olave, Charitharth Vivek Lal, Brian Halloran, Vineet Bhandari, Namasivayam Ambalavanan

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Cyclooxygenase-2 deficiency attenuates lipopolysaccharide-induced inflammation, apoptosis, and acute lung injury in adult mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Article
  8. Article
  9. Review
  10. Effects of hyperoxia on alveolar and pulmonary vascular development in germ-free mice.American journal of physiology. Lung cellular and molecular physiology · 2020
    Article
  11. Article
  12. Article
  13. Asiaticoside attenuates hyperoxia-induced lung injuryIranian journal of basic medical sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nelida OlaveDepartment of Pediatrics, University of Alabama at Birmingham , Birmingham, Alabama.
Charitharth Vivek LalDepartment of Pediatrics, University of Alabama at Birmingham , Birmingham, Alabama.ORCID 0000-0001-9071-4047
Brian HalloranDepartment of Pediatrics, University of Alabama at Birmingham , Birmingham, Alabama.
Vineet BhandariDepartment of Pediatrics, Drexel University College of Medicine , Philadelphia, Pennsylvania.
Namasivayam AmbalavananDepartment of Pediatrics, University of Alabama at Birmingham , Birmingham, Alabama.
University of Alabama at Birmingham · USDrexel University · US

Funding

Alveolar DevMAPU01HL122626 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMBALAVANAN, NAMASIVAYAM, HAGOOD, JAMES S. · 2014 to 2018
$3.7M
TRANSFORMING GROWTH FACTOR - BETA MEDIATES EFFECTS OF HYPOXIA IN NEWBORN LUNGR01HL092906 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMBALAVANAN, NAMASIVAYAM · 2008 to 2012
$1.9M
NHLBI NIH HHS R01 HL092906NHLBI NIH HHS U01 HL122626
6 · The paper itself

Abstract

Cyclooxygenase-2 (COX-2/PTGS2) mediates hyperoxia-induced impairment of lung development in newborn animals and is increased in the lungs of human infants with bronchopulmonary dysplasia (BPD). COX-2 catalyzes the production of cytoprotective prostaglandins, such as prostacyclin (PGI

Indexed as

AnimalsAnimals, NewbornBronchopulmonary DysplasiaDisease Models, AnimalFemaleHyperoxiaIloprostMiceMice, Inbred C57BLPneumoniaPregnancyPulmonary AlveoliVasodilator AgentsIloprostVasodilator Agentsinfant, newbornlung developmentoxidative stressprostacyclin

Identifiers

PMID29952221
PMCPMC6230878
OpenAlexW2810138159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.