ReviewAmerican journal of physiology. Lung cellular and molecular physiology2018
Mechanisms of organophosphorus pesticide toxicity in the context of airway hyperreactivity and asthma.
Review in American journal of physiology. Lung cellular and molecular physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- A national toxicology program systematic review of the evidence for long-term effects after acute exposure to sarin nerve agent.Critical reviews in toxicology · 2020Pooled it
- Heavy moms, wheezy kids: how maternal obesity harms breathing in offspring.American journal of respiratory cell and molecular biology · 2026Review
- Impact of Pesticide Exposure on Asthma and Allergic Airway Disease.Current allergy and asthma reports · 2026Review
- Associations of PFAS and pesticides with lung function changes from adolescence to young adulthood in the ESPINA study.International journal of hygiene and environmental health · 2025Article
- Characterization of pesticide exposures and their associations with asthma morbidity in a predominantly low-income urban pediatric cohort in Baltimore City.Environmental research · 2024Article
- Pesticides as an overlooked exposomic association in allergic asthma exacerbations: A nationwide database study.Allergy · 2024Article
- Exposure to agricultural pesticides and wheezing among 5-12-year-old children in the Imperial Valley, CA, USA.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Association between organophosphorus insecticides exposure and osteoarthritis in patients with arteriosclerotic cardiovascular disease.BMC public health · 2024Article
- Impact of chlorpyrifos exposure on lung function in Egyptian adolescent agriculture workers.Archives of environmental & occupational health · 2024Article
- Hypoactivity and neurochemical alterations in the basal ganglia of female Sprague-Dawley rats after repeated exposure to atrazine.Frontiers in toxicology · 2024Article
- Paper-Based Electrochemical Biosensors for Food Safety Analysis.Biosensors · 2022Review
- Respiratory and allergic health effects in children living near agriculture: A review.The Science of the total environment · 2022Review
- Clinical and Epidemiological Characteristics of Acute Poisoning in Children in Southwestern China: A Review of 1755 Cases from 2014 to 2020.International journal of general medicine · 2022Article
- Insecticide Exposure and Risk of Asthmatic Symptoms: A Systematic Review and Meta-Analysis.Toxics · 2021Review
- Effects of Chlorpyrifos on Serine Hydrolase Activities, Lipid Mediators, and Immune Responses in Lungs of Neonatal and Adult Mice.Chemical research in toxicology · 2021Article
- Article
- Pesticide exposure and rhinitis: A cross-sectional study among farmers in Pitsanulok, Thailand.F1000Research · 2021Article
- Exposure to organophosphorus insecticides and increased risks of health and cancer in US women.Environmental toxicology and pharmacology · 2020Article
- Asthma without borders.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Organophosphorus Pesticides Induce Cytokine Release from Differentiated Human THP1 Cells.American journal of respiratory cell and molecular biology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Numerous epidemiologic studies have identified an association between occupational exposures to organophosphorus pesticides (OPs) and asthma or asthmatic symptoms in adults. Emerging epidemiologic data suggest that environmentally relevant levels of OPs may also be linked to respiratory dysfunction in the general population and that in utero and/or early life exposures to environmental OPs may increase risk for childhood asthma. In support of a causal link between OPs and asthma, experimental evidence demonstrates that occupationally and environmentally relevant OP exposures induce bronchospasm and airway hyperreactivity in preclinical models. Mechanistic studies have identified blockade of autoinhibitory M2 muscarinic receptors on parasympathetic nerves that innervate airway smooth muscle as one mechanism by which OPs induce airway hyperreactivity, but significant questions remain regarding the mechanism(s) by which OPs cause neuronal M2 receptor dysfunction and, more generally, how OPs cause persistent asthma, especially after developmental exposures. The goals of this review are to 1) summarize current understanding of OPs in asthma; 2) discuss mechanisms of OP neurotoxicity and immunotoxicity that warrant consideration in the context of OP-induced airway hyperreactivity and asthma, specifically, inflammatory responses, oxidative stress, neural plasticity, and neurogenic inflammation; and 3) identify critical data gaps that need to be addressed in order to better protect adults and children against the harmful respiratory effects of low-level OP exposures.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.