Evidence map›Paper›PMID 29952137›Full record

Trial reportPhysiological reports2018

Inspiratory and expiratory resistance cause right-to-left bubble passage through the foramen ovale.

Kayla L Moses, McKayla Seymour, Arij Beshish, Kim R Baker, David F Pegelow, Luke J Lamers, Marlowe W Eldridge, Melissa L Bates

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Patent Foramen Ovale in Fetal Life, Infancy and Childhood.Medical sciences (Basel, Switzerland) · 2020
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Kayla L MosesJohn Rankin Laboratory of Pulmonary Medicine, Department of Pediatrics, Critical Care Division, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
McKayla SeymourDepartment of Health and Human Physiology, University of Iowa, Iowa City, Iowa.
Arij BeshishJohn Rankin Laboratory of Pulmonary Medicine, Department of Pediatrics, Critical Care Division, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Kim R BakerAdult Echocardiography Laboratory, University of Wisconsin Hospitals and Clinics, Madison, Wisconsin.
David F PegelowJohn Rankin Laboratory of Pulmonary Medicine, Department of Pediatrics, Critical Care Division, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Luke J LamersDivision of Pediatric Cardiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Marlowe W EldridgeJohn Rankin Laboratory of Pulmonary Medicine, Department of Pediatrics, Critical Care Division, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Melissa L BatesDepartment of Health and Human Physiology, University of Iowa, Iowa City, Iowa.ORCID 0000-0002-2605-0984
University of Wisconsin–Madison · USUniversity of Iowa · USUW Health University Hospital · US

Funding

Right Heart-Pulmonary Vascular Interactions in Bronchopulmonary DysplasiaR01HL115061 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI ELDRIDGE, MARLOWE · 2012 to 2016
$3.2M
Comprehensive Characterization of Intrapulmonary Arteriovenous Pathways in HealthR01HL086897 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI ELDRIDGE, MARLOWE · 2008 to 2012
$1.8M
NHLBI NIH HHS R01 HL086897NHLBI NIH HHS R01 HL115061
6 · The paper itself

Abstract

A patent foramen ovale (PFO) is linked to increased risk of decompression illness in divers. One theory is that venous gas emboli crossing the PFO can be minimized by avoiding lifting, straining and Valsalva maneuvers. Alternatively, we hypothesized that mild increases in external inspiratory and expiratory resistance, similar to that provided by a SCUBA regulator, recruit the PFO. Nine healthy adults with a Valsalva-proven PFO completed three randomized trials (inspiratory, expiratory, and combined external loading) with six levels of increasing external resistance (2-20 cmH

Indexed as

AdolescentAdultAirway ResistanceEchocardiographyEmbolism, AirEsophagusExhalationFemaleForamen OvaleForamen Ovale, PatentHumansInhalationMaleYoung AdultAirway resistancedivingpatent foramen ovaleshuntstrokework of breathing

Identifiers

PMID29952137
PMCPMC6021277
OpenAlexW2810314796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.