ArticleThe Plant journal : for cell and molecular biology2018
The genetic architecture of genome-wide recombination rate variation in allopolyploid wheat revealed by nested association mapping.
Article in The Plant journal : for cell and molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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64 citing papers in PubMed.
- The role of methylation and structural variants in shaping the recombination landscape of barley.The Plant journal : for cell and molecular biology · 2026Article
- Mapping recombination cold spots in wheat via meiotic recombination in a large biparental population.G3 (Bethesda, Md.) · 2026Article
- Genetic architecture and candidate loci associated with growth and yield-related traits in sweet fig banana (Musa acuminata cv Sotoumon, AA).BMC genomics · 2026Article
- High resolution mapping and development of diagnostic KASP markers for FHB resistance QTL on chromosome 1B in an elite soft red winter wheat cultivar 'Jamestown'.Molecular breeding : new strategies in plant improvement · 2026Article
- An overview of recent advances on wheat homologous and homoeologous recombination.Journal of experimental botany · 2026Review
- Genomic introgressions from wild relatives in the wheat genome alter meiotic dynamics in inter-varietal hybrids.The Plant journal : for cell and molecular biology · 2026Article
- X-cross/over: a web tool for graph-based estimation of meiotic crossover events in plants.BMC bioinformatics · 2025Article
- Mixed Outcomes in Recombination Rates After Domestication: Revisiting Theory and Data.Molecular ecology · 2025Review
- Development and characterization of a wild emmer wheat backcross introgression population for hard winter wheat improvement.The plant genome · 2025Article
- Genetics of recombination rate variation within and between species.Journal of evolutionary biology · 2025Article
- A 25K Wheat SNP Array Revealed the Genetic Diversity and Population Structure of Durum Wheat (International journal of molecular sciences · 2025Article
- Plant Productivity and Leaf Starch During Grain Fill Is Linked to QTL Containing Flowering Locus T1 (Plants (Basel, Switzerland) · 2025Article
- Review
- Accumulation ofFrontiers in plant science · 2025Article
- Drought-tolerant wheat for enhancing global food security.Functional & integrative genomics · 2024Review
- A new winter wheat genetic resource harbors untapped diversity from synthetic hexaploid wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Comparing performances of different statistical models and multiple threshold methods in a nested association mapping population of wheat.Frontiers in plant science · 2024Article
- Article
- Identification of structural variations related to drought tolerance in wheat (Triticum aestivum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Global dissection of the recombination landscape in soybean using a high-density 600K SoySNP array.Plant biotechnology journal · 2023Article
4 more citing papers are in PubMed but not listed here.
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15 authors.
Funding
Abstract
Recombination affects the fate of alleles in populations by imposing constraints on the reshuffling of genetic information. Understanding the genetic basis of these constraints is critical for manipulating the recombination process to improve the resolution of genetic mapping, and reducing the negative effects of linkage drag and deleterious genetic load in breeding. Using sequence-based genotyping of a wheat nested association mapping (NAM) population of 2,100 recombinant inbred lines created by crossing 29 diverse lines, we mapped QTL affecting the distribution and frequency of 102 000 crossovers (CO). Genome-wide recombination rate variation was mostly defined by rare alleles with small effects together explaining up to 48.6% of variation. Most QTL were additive and showed predominantly trans-acting effects. The QTL affecting the proximal COs also acted additively without increasing the frequency of distal COs. We showed that the regions with decreased recombination carry more single nucleotide polymorphisms (SNPs) with possible deleterious effects than the regions with a high recombination rate. Therefore, our study offers insights into the genetic basis of recombination rate variation in wheat and its effect on the distribution of deleterious SNPs across the genome. The identified trans-acting additive QTL can be utilized to manipulate CO frequency and distribution in the large polyploid wheat genome opening the possibility to improve the efficiency of gene pyramiding and reducing the deleterious genetic load in the low-recombining pericentromeric regions of chromosomes.
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