Evidence map›Paper›PMID 29951964›Full record

ReviewRheumatology international2018

C3 glomerulopathy in NLRP12-related autoinflammatory disorder: case-based review.

Özge Başaran, Nermin Uncu, Nilgün Çakar, Eda Tahir Turanlı, Saba Kiremitci, Fatma Aydın, Umut Selda Bayrakcı

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Rheumatology international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. RMD open · 2023
    Review
  2. Article
  3. Article
  4. NLRP12-associated systemic autoinflammatory diseases in children.Pediatric rheumatology online journal · 2022
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Özge BaşaranPediatric Rheumatology, Ankara Child Health and Disease Hematology Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey. ozgesalor@yahoo.com.ORCID http://orcid.org/0000-0002-8534-0930
Nermin UncuPediatric Rheumatology, Ankara Child Health and Disease Hematology Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey.ORCID http://orcid.org/0000-0001-9170-3956
Nilgün ÇakarDepartment of Pediatric Rheumatology, Ankara University School of Medicine, Ankara, Turkey.ORCID http://orcid.org/0000-0002-1853-0101
Eda Tahir TuranlıDivision of Molecular Biology and Genetics, Faculty of Science and Literature, İstanbul Technical University, Istanbul, Turkey.
Saba KiremitciDepartment of Pathology, Ankara University School of Medicine, Ankara, Turkey.ORCID http://orcid.org/0000-0001-8868-1362
Fatma AydınPediatric Rheumatology, Ankara Child Health and Disease Hematology Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey.ORCID http://orcid.org/0000-0003-0306-7473
Umut Selda BayrakcıDepartment of Pediatric Nephrology, Yıldırım Beyazıt University, Ankara, Turkey.ORCID http://orcid.org/0000-0002-5301-2617
Ministry of Health · TRAnkara University · TRAnkara Yıldırım Beyazıt University · TRIstanbul Technical University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoinflammatory diseases (AIDs) are a recently described group of conditions caused by mutations in multiple genes that code for proteins of the innate immune system. Cryopyrin-associated periodic syndromes (CAPS) are autoinflammatory diseases comprising three clinically overlapping disorders: familial cold urticarial syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease (NOMID). CAPS have been associated with gain-of-function variations in NLRP3 (NOD-like receptor family, pyrin containing domain-3). However, a new class of autoinflammatory disease resembling FCAS or MWS has been described in patients with NLRP12 mutations. Here, we report a 6-year-old boy diagnosed with AID who developed an unexpected C3 glomerulopathy during attacks and carried a novel variation in NLRP12. Following treatment with IL (interleukin) 1 targeting agents, all symptoms and inflammation resolved. This is the first case in the literature affected by both autoinflammatory disease and C3 glomerulopathy.

Indexed as

Adenosine DeaminaseCARD Signaling Adaptor ProteinsChildCryopyrin-Associated Periodic SyndromesExonsGermanyGuanylate CyclaseHereditary Autoinflammatory DiseasesHumansIntercellular Signaling Peptides and ProteinsInterleukin-1Intracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMutationNLR Family, Pyrin Domain-Containing 3 ProteinADA2 protein, humanAdenosine DeaminaseCARD14 protein, humanCARD Signaling Adaptor ProteinsGuanylate CyclaseIntercellular Signaling Peptides and ProteinsInterleukin-1Intracellular Signaling Peptides and ProteinsMEFV protein, humanMembrane ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinNLRP12 protein, humanNucleoside Transport ProteinsPyrinSLC29A3 protein, humanAutoinflammatory diseaseC3 glomerulopathyNLRP12Pediatric

Identifiers

PMID29951964
OpenAlexW2811444359

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.