Evidence map›Paper›PMID 29951958›Full record

SynthesisNeurocritical care2019

A Systematic Review of Outcome Measures Employed in Aneurysmal Subarachnoid Hemorrhage (aSAH) Clinical Research.

Christopher R Andersen, Emily Fitzgerald, Anthony Delaney, Simon Finfer

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neurocritical care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 5 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 5 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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  15. Outcomes Measures in Subarachnoid Hemorrhage Research.Translational stroke research · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Christopher R AndersenMalcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St Leonards, NSW, 2065, Australia. christopher.andersen@ndcn.ox.ac.uk.ORCID http://orcid.org/0000-0002-9321-8660
Emily FitzgeraldMalcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St Leonards, NSW, 2065, Australia.
Anthony DelaneyMalcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St Leonards, NSW, 2065, Australia.
Simon FinferMalcolm Fisher Department of Intensive Care Medicine, Royal North Shore Hospital, St Leonards, NSW, 2065, Australia.
Royal North Shore Hospital · AUThe George Institute for Global Health · GBThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Consensus on appropriate outcome measures to use in aneurysmal subarachnoid hemorrhage (aSAH) research has not been established, although the transition toward a core outcome set (COS) would provide significant benefits. To inform COS development, we conducted a systematic review to identify outcome measures included in reports of randomized clinical trials (RCTs) of interventions in patients with aSAH. Ovid Medline, EMBASE, CINAHL, and CENTRAL were searched. RCTs investigating aSAH published between January 1996 and May 2015 were included. The primary and secondary outcomes of RCTs were recorded and classified according to the OMERACT Consortium's framework. We identified 1093 potential studies of which 129 met inclusion criteria representing 24 238 patients. There were 285 unique outcome measures. The Glasgow Outcome Scale (GOS) was the most frequently used primary outcome (13/129, 10.1%). Mortality was reported in 84 trials (65.1%) with 3 months the most common time point (34/129, 26.4%). The GOS (65/129, 50.4%) and the Modified Rankin Scale (51/129, 39.5%) were the most commonly reported functional measures; however, these were reported at different time points and often dichotomized using different ranges. Patient-reported quality of life measures were used in 11 trials (8.5%). Transcranial Doppler was the most frequently used imaging modality (40/129, 31.0%). Definitions and reporting of vasospasm, delayed cerebral ischemia and imaging modality results were highly variable. The marked heterogeneity of outcomes in reports of RCTs supports the development of a core outcome set for aSAH trials. Our study has identified a wide range of outcomes for potential inclusion in a future aSAH COS.

Indexed as

Glasgow Outcome ScaleIntracranial AneurysmOutcome Assessment, Health CareSubarachnoid HemorrhageHumansCritical care outcomesGlasgow Outcome ScaleIntracranial aneurysmOutcome assessment (health care)Patient-reported outcome measuresStrokeSubarachnoid hemorrhage

Identifiers

PMID29951958
OpenAlexW2811215747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.