Evidence map›Paper›PMID 29951889›Full record

ReviewCurrent hematologic malignancy reports2018

Molecular Insights Into Pathogenesis of Peripheral T Cell Lymphoma: a Review.

Waseem Lone, Aisha Alkhiniji, Jayadev Manikkam Umakanthan, Javeed Iqbal

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current hematologic malignancy reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Gene Expression Signatures for the Accurate Diagnosis of Peripheral T-Cell Lymphoma Entities in the Routine Clinical Practice.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
    Article
  5. Article
  6. Review
  7. Genome-Wide miRNA Expression Profiling of Molecular Subgroups of Peripheral T-cell Lymphoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. [How I diagnose and treat peripheral T cell lymphoma].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Waseem LoneDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198-6842, USA.
Aisha AlkhinijiDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198-6842, USA.
Jayadev Manikkam UmakanthanDepartment of Internal Medicine, Division of Oncology & Hematology, University of Nebraska Medical Center, Omaha, NE, 68198-6842, USA.
Javeed IqbalDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, 68198-6842, USA. jiqbal@unmc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewPeripheral T cell lymphoma (PTCL) is a heterogeneous group of lymphoproliferative neoplasms, with at least 29 distinct entities described in current WHO classification. Using present diagnostic approaches, more than a third of PTCL cases cannot be classified, hence designated as PTCL-not otherwise specified (PTCL-NOS). Herein, we summarize the current genomic findings and their role in the molecular pathogenesis in different PTCL entities. RECENT

findingsGene expression profiling (GEP) studies have identified distinct molecular signatures for accurate diagnosis and elucidated oncogenic pathways enriched in major PTCL entities. Furthermore, genomic characterization has identified recurrent somatic mutations and potential therapeutic targets. Further efforts are underway to develop genetically faithful murine models. GEP studies have identified molecular subgroups of PTCL, characterized by distinct genetic and epigenetic alterations. Understanding the molecular mechanisms of T cell lymphomagenesis using in vivo model will help to reveal novel therapeutic targets.

Indexed as

Gene Expression ProfilingGene Expression Regulation, NeoplasticLymphoma, T-Cell, PeripheralAnimalsHumansMiceNeoplasms, ExperimentalWorld Health OrganizationAnaplastic large cell lymphomaAngioimmunoblastic T cell lymphomaGene expression profilingMolecular signaturePeripheral T cell lymphoma-not otherwise specifiedPTCL

Identifiers

PMID29951889

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.