Evidence map›Paper›PMID 29951847›Full record

ArticleMolecular imaging and biology2019

In Vivo Mapping and Quantification of Creatine Using Chemical Exchange Saturation Transfer Imaging in Rat Models of Epileptic Seizure.

Dong-Hoon Lee, Do-Wan Lee, Jae-Im Kwon, Chul-Woong Woo, Sang-Tae Kim, Jin Seong Lee, Choong Gon Choi, Kyung Won Kim, Jeong Kon Kim, Dong-Cheol Woo

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. A fast multislice sequence for 3D MRI-CEST pH imaging.Magnetic resonance in medicine · 2021
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dong-Hoon LeeFaculty of Health Sciences and Brain & Mind Centre, The University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-5013-4440
Do-Wan LeeCenter for Bioimaging of New Drug Development, and MR Core Laboratory, Asan Medical Center, Asan Institute for Life Sciences, Seoul, Republic of Korea.
Jae-Im KwonMR Core Laboratory, Asan Medical Center, Asan Institute for Life Sciences, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Republic of Korea.
Chul-Woong WooMR Core Laboratory, Asan Medical Center, Asan Institute for Life Sciences, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Republic of Korea.
Sang-Tae KimMR Core Laboratory, Asan Medical Center, Asan Institute for Life Sciences, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Republic of Korea.
Jin Seong LeeDepartment of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Choong Gon ChoiDepartment of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Kyung Won KimDepartment of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Jeong Kon KimDepartment of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Dong-Cheol WooMR Core Laboratory, Asan Medical Center, Asan Institute for Life Sciences, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Republic of Korea. dcwoo@amc.seoul.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate signal changes in the hippocampus of epileptic seizure rat models, based on quantified creatine chemical exchange saturation transfer (CrCEST) signals. PROCEDURES: CEST data and

resultsMeasured CrCEST signals were exhibited significant differences between before and after KA injection in the ES group. At each time point, CrCEST signals showed significant correlations with PCr concentration (all |r| > 0.59; all P < 0.05); no significant correlations were found between CrCEST signals and tCr concentrations (all |r| < 0.22; all P > 0.05).

conclusionsCrCEST can adequately detect changes in the concentration of Cr as a result of energy metabolism, and may serve as a potentially useful tool for diagnosis and assessment of prognosis in epilepsy.

Indexed as

AnimalsCreatineDisease Models, AnimalImage Processing, Computer-AssistedMagnetic Resonance SpectroscopyMalePhosphocreatineRats, WistarSeizuresCreatinePhosphocreatineChemical exchange saturation transferCreatineEpilepsyMagnetic resonance spectroscopyPhosphocreatine

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.