ReviewClinical research in cardiology : official journal of the German Cardiac Society2018
Hypertension: history and development of established and novel treatments.
Review in Clinical research in cardiology : official journal of the German Cardiac Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Systematic review of renal denervation for the management of cardiac arrhythmias.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Pooled it
- Seven Deadly Sins in Hypertension Management: In-Depth Analysis of the Errors on a Journey from Riva-Rocci to Myocardial Fibrosis.Arquivos brasileiros de cardiologia · 2025Review
- Non-invasive evaluation of retinal vascular remodeling and hypertrophy in humans: intricate effect of ageing, blood pressure and glycaemia.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Article
- The Association of Stage 1 Hypertension, Defined by the 2017 ACC/AHA Guidelines, With Cardiovascular Events Among Rural Women in Liaoning Province, China.Frontiers in cardiovascular medicine · 2021Article
- The association of conventionally medicated systolic and diastolic blood pressure level and mortality from cardiovascular disease: is the lower the better in high stroke population?Clinical research in cardiology : official journal of the German Cardiac Society · 2020Article
- Body mass index modifies the association between frequency of alcohol consumption and incidence of hypertension in men but not in women: a retrospective cohort study.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Renal Denervation: Is It Ready for Prime Time?Current cardiology reports · 2019Review
- Cardiac-specific overexpression of metallothionein attenuates L-NAME-induced myocardial contractile anomalies and apoptosis.Journal of cellular and molecular medicine · 2019Article
- Observational
- Cardiovascular risk factors are important determinants of platelet-dependent thrombin generation in adult survivors of childhood cancer.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis article summarizes the emerging field of hypertension over the last decades. It covers paradigm shifts on hypertension from an undefined cardiovascular condition to the most relevant cardiovascular modifiable risk factor and the developments of drug treatments and interventional treatments to improve cardiovascular outcomes.
methodsWe performed a selective literature research in PubMed on trials published in the past until 2018 without time restrictions and covered unpublished trials disclosed in ClinicalTrials.org.
resultsThe development of treatments of hypertension is a success story covering many decades from the early attempts with drug treatments, development of tolerable and effective medications to interventional techniques involving renal denervation, AV fistulas, and autonomic devices. Novel guidelines define new definitions and treatment targets of hypertension, which are a matter of ongoing discussion.
conclusionDespite the development of tolerable and effective drugs, new treatments in the field of neuroendocrine modulation by drugs and devices are still under development trying to further improve treatment of patients with hypertension and to further reduce cardiovascular events in those individuals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.