ArticleBJS open2017
Multicentre observational study of quality of life after surgical palliation of malignant gastric outlet obstruction for gastric cancer.
Article in BJS open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Japanese gastric cancer treatment guidelines 2025 (7th edition).Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Guideline
- Meta-analysis of the efficacy of applying reduced surgery for the treatment of asymptomatic unresectable advanced gastric cancer.BMC gastroenterology · 2025Pooled it
- Peri-operative Outcomes and Survival Following Palliative Gastrectomy for Gastric Cancer: a Systematic Review and Meta-analysis.Journal of gastrointestinal cancer · 2021Pooled it
- Trial
- Treatment Pathways and Outcomes in Unresectable Gastric Cancer: A Retrospective Cohort Analysis.Cureus · 2025Article
- Stents and Emerging Alternatives in Upper Gastrointestinal Endoscopy: A Comprehensive Review.Diagnostics (Basel, Switzerland) · 2025Review
- Unveiling hidden outcomes in malignant gastric outlet obstruction research - insights from a "Pancreas 2000" review.World journal of gastrointestinal endoscopy · 2024Review
- Palliative Surgery for Patients with Gastroesophageal Junction or Gastric Cancer: A Report on Clinical Observational Outcomes.Annals of surgical oncology · 2024Observational
- Endoscopic ultrasound-guided gastrojejunostomy for benign gastric outlet obstruction (GOO): a retrospective analysis of patients and outcomes.Surgical endoscopy · 2024Article
- Palliative surgery: state of the science and future directions.The British journal of surgery · 2024Article
- Development and verification of a nomogram for predicting the prognosis of resectable gastric cancer with outlet obstruction.BMC cancer · 2022Article
- Survival analysis of a prospective multicenter observational study on surgical palliation among patients with malignant bowel obstruction caused by peritoneal dissemination of gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2022Observational
- Article
- QOL assessment after palliative surgery for malignant bowel obstruction caused by peritoneal dissemination of gastric cancer: a prospective multicenter observational study.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2021Observational
- Survival analysis of a prospective multicenter observational study on surgical palliation among patients receiving treatment for malignant gastric outlet obstruction caused by incurable advanced gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2021Observational
- Relationship between initial management strategy and survival in patients with gastric outlet obstruction due to gastric cancer.Journal of surgical oncology · 2020Article
- Clinical outcome of a highly flexible duodenal stent for gastric outlet obstruction: A multicenter prospective study.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- EUS-guided gastroenteric anastomosis as a bridge to definitive treatment in benign gastric outlet obstruction.Gastrointestinal endoscopy · 2020Article
Corrections and comments
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Authors and funding
10 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundQuality of life (QoL) is a key component in decision-making for surgical palliation, but QoL data in association with surgical palliation in advanced gastric cancer are scarce. The aim of this multicentre observational study was to examine the impact of surgical palliation on QoL in advanced gastric cancer.
methodsThe study included patients with gastric outlet obstruction caused by incurable advanced primary gastric cancer who had no oral intake or liquid intake only. Patients underwent palliative distal/total gastrectomy or bypass surgery at the physician's discretion. The primary endpoint was change in QoL assessed at baseline, 14 days, 1 month and 3 months following surgical palliation by means of the EuroQoL Five Dimensions (EQ-5D™) questionnaire and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire gastric cancer module (QLQ-STO22). Secondary endpoints were postoperative improvement in oral intake and surgical complications.
resultsSome 104 patients (23 distal gastrectomy, 9 total gastrectomy, 70 gastrojejunostomy, 2 exploratory laparotomy) were enrolled from 35 institutions. The mean EQ-5D™ utility index scores remained consistent, with a baseline score of 0·74 and the change from baseline within ± 0·05. Gastric-specific symptoms showed statistically significant improvement from baseline. The majority of patients were able to eat solid food 2 weeks after surgery and tolerated it thereafter. The rate of overall morbidity of grade III or more according to the Clavien-Dindo classification was 9·6 per cent (10 patients) and the 30-day postoperative mortality rate was 1·9 per cent (2 patients).
conclusionIn patients with gastric outlet obstruction caused by advanced gastric cancer, surgical palliation maintained QoL while improving solid food intake, with acceptable morbidity for at least the first 3 months after surgery. Registration number 000023494 (UMIN Clinical Trials Registry).
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Registered trials
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