ReviewBJS open2017
Systematic review and meta-analysis of frailty as a predictor of morbidity and mortality after major abdominal surgery.
Review in BJS open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04729738 (The Impact of Comorbidities, Frailty Malnutrition and Sarcopenia on Short-term Mortality in Patients Undergoing Laparoscopic Colon Surgery), which is not on this map. Cited by 55 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Comorbidities, Frailty Malnutrition and Sarcopenia on Short-term Mortality in Patients Undergoing Laparoscopic Colon Surgery
Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of prehabilitation programmes on postoperative outcomes in older adults undergoing major abdominal, cardiac or vascular surgery: a systematic review.Aging clinical and experimental research · 2026Pooled it
- Effect of sarcopenia on survival in patients after pancreatic surgery: a systematic review and meta-analysis.Frontiers in nutrition · 2023Pooled it
- Differences in clinical presentation and treatment decisions between frail and not-frail head and neck cancer patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Contemporary preoperative assessment for colorectal surgery: new insights and developments.BMJ open gastroenterology · 2026Review
- Frailty in Hepatocellular Carcinoma: An Unsettled Clinical Challenge.Current oncology (Toronto, Ont.) · 2026Review
- Safety of In-Hospital Delay of Appendectomy in Elderly Patients-A Retrospective Analysis of 525 Consecutive Patients Aged 65 and Older Undergoing Surgery for Suspected Appendicitis.World journal of surgery · 2026Article
- Article
- Frailty: from concept to clinical practice in urology.Frontiers in medicine · 2026Review
- Association of Frailty and Postoperative Outcomes across Race and Ethnicity.Journal of racial and ethnic health disparities · 2025Article
- Phase angle as a prognostic factor for postoperative outcomes in major abdominal surgery: a single-center prospective observational study.Journal of anesthesia · 2025Observational
- A survey of perioperative medicine services with a focus on provision for older surgical patients in the UK and Republic of Ireland: SNAP-3.British journal of anaesthesia · 2025Article
- Psoas muscle density predicts elective colorectal surgical outcomes more accurately than psoas muscle area or indexed area.The Journal of frailty & aging · 2025Article
- Frailty and body composition predict adverse outcomes after emergency general surgery admission: a multicentre observational cohort study.Annals of the Royal College of Surgeons of England · 2025Observational
- The effect of delirium on the association between frailty and postoperative major complications in elderly patients: a mediation analysis.Journal of anesthesia · 2025Article
- Enhanced recovery after laparoscopic distal gastrectomy using articulating laparoscopic instruments in older adults with gastric cancer: a retrospective analysis of prospectively collected data.Annals of surgical treatment and research · 2025Article
- Minimally invasive surgery versus open gastrectomy for older patients with gastric cancer: A propensity score-matching analysis.Annals of gastroenterological surgery · 2025Article
- Article
- Effect of Frailty on Postoperative Outcomes Following Major Abdominal Surgeries: A Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Comprehensive Peri-Operative Risk Assessment and Management of Geriatric Patients.Diagnostics (Basel, Switzerland) · 2024Review
- Evaluation of a new two-step frailty assessment of head and neck patients in a prospective cohort.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrailty is associated with poor prognosis, but the multitude of definitions and scales of assessment makes the impact on outcomes difficult to assess. The aim of this study was to quantify the effect of frailty on postoperative morbidity and mortality, and long-term mortality after major abdominal surgery, and to evaluate the performance of different frailty metrics.
methodsAn extended literature search was performed to retrieve all original articles investigating whether frailty could affect outcomes after elective major abdominal surgery in adult populations. All possible definitions of frailty were considered. A random-effects meta-analysis was carried out for all outcomes of interest. For postoperative morbidity and mortality, overall effect sizes were estimated as odds ratios (OR), whereas the hazard ratio (HR) was calculated for long-term mortality. The potential effect of the number of domains of the frailty indices was explored through meta-regression at moderator analysis.
resultsA total of 35 studies with 1 153 684 patients were analysed. Frailty was associated with a significantly increased risk of postoperative major morbidity (OR 2·56, 95 per cent c.i. 2·08 to 3·16), short-term mortality (OR 5·77, 4·41 to 7·55) and long-term mortality (HR 2·71, 1·63 to 4·49). All domains were significantly associated with the occurrence of postoperative major morbidity, with ORs ranging from 1·09 (1·00 to 1·18) for co-morbidity to 2·52 (1·32 to 4·80) for sarcopenia. No moderator effect was observed according to the number of frailty components.
conclusionRegardless of the definition and combination of domains, frailty was significantly associated with an increased risk of postoperative morbidity and mortality after major abdominal surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.