ArticleNutrition and healthy aging2018
Curcumin supplementation and motor-cognitive function in healthy middle-aged and older adults.
Article in Nutrition and healthy aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effects of Zingiberaceae-derived interventions on memory-related and other cognitive outcomes in adults: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Effect of host and gut microbiota-altering interventions on sarcopenia or its defining parameters: a systematic review and meta-analysis of nutrition-based intervention studies.Aging clinical and experimental research · 2025Pooled it
- Targeting cognitive aging with curcumin supplementation: A systematic review and meta-analysis.The journal of prevention of Alzheimer's disease · 2025Pooled it
- Short-term time-restricted feeding is safe and feasible in non-obese healthy midlife and older adults.GeroScience · 2020Trial
- Salutary effects of transdermal curcumin on multiple indices of health span in rodent models of normal aging and hypertension.GeroScience · 2025Article
- Highly Bioavailable Curcumin, but Not Native Curcumin, Combined With Exercise Improves Cognitive Function in Mice.Food science & nutrition · 2025Article
- Repetitive element transcript accumulation is associated with inflammaging in humans.GeroScience · 2024Article
- Curcumin Supplementation and Vascular and Cognitive Function in Chronic Kidney Disease: A Randomized Controlled Trial.Antioxidants (Basel, Switzerland) · 2024Article
- Curcumin Supplementation and Human Disease: A Scoping Review of Clinical Trials.International journal of molecular sciences · 2023Article
- The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence.Antioxidants (Basel, Switzerland) · 2022Review
- Extracellular to Intracellular Body Water and Cognitive Function among Healthy Older and Younger Adults.Journal of functional morphology and kinesiology · 2022Article
- Inflammaging and Brain: Curcumin and Its Beneficial Potential as Regulator of Microglia Activation.Molecules (Basel, Switzerland) · 2022Review
- Curcumin Alleviates the Senescence of Canine Bone Marrow Mesenchymal Stem Cells during In Vitro Expansion by Activating the Autophagy Pathway.International journal of molecular sciences · 2021Article
- Dietary Interventions to Prevent or Delay Alzheimer's Disease: What the Evidence Shows.Current nutrition reports · 2020Review
- Curcumin Attenuates Lead-Induced Cerebellar Toxicity in Rats via Chelating Activity and Inhibition of Oxidative Stress.Biomolecules · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundRecent studies suggest curcumin is a promising nutraceutical for improving important clinical and physiological markers of healthy aging, including motor and cognitive function.
objectiveTo determine if curcumin supplementation improves motor and cognitive function in healthy middle-aged and older adults.
methods39 healthy men and postmenopausal women (45-74 yrs) were randomized to 12 weeks of placebo (
resultsUsing measures of the NIH Toolbox and other standardized tests, there were no changes in muscle strength and rate of torque development, dexterity, fatigability, mobility, endurance, and balance between the placebo and curcumin groups after 12 weeks (all
conclusionsOverall, 12 weeks of curcumin supplementation does not improve motor and cognitive functions in healthy middle-aged and older adults. It is possible that curcumin may enhance these functions in groups with greater baseline impairments than those studied here, including adults greater than 75 years of age and/or patients with clinical disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.