Evidence map›Paper›PMID 29951588›Full record

ReviewNutrition and healthy aging2018

Gut microbiome and aging: Physiological and mechanistic insights.

Ravinder Nagpal, Rabina Mainali, Shokouh Ahmadi, Shaohua Wang, Ria Singh, Kylie Kavanagh, Dalane W Kitzman, Almagul Kushugulova, Francesco Marotta, Hariom Yadav

Registry-linked trialAbstract readReview
In one paragraph

Review in Nutrition and healthy aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04447144 (Nutritional Habits, Does it Affect Coronavirus Disease 2019), which is not on this map. Cited by 349 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
349citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04447144 unknown statusnot on this mapstarted 2020, after this paper: background citation

Nutritional Habits, Does it Affect Coronavirus Disease 2019 (COVID-19) Infection Outcome? An Egyptian Experience

TypeobservationalSponsorCairo UniversityRan2020 to 2020Enrolled200ConditionsCovid19, Chronic Inflammation, Non-Communicable Chronic Diseases
3 · Its place in the literature

Who cites it

349 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Review
  11. Review
  12. Establishment of anmSystems · 2026
    Article
  13. Review
  14. Review
  15. Article
  16. Gut microbiota and disease.Essays in biochemistry · 2026
    Article
  17. Review
  18. Review
  19. Review
  20. Review

289 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ravinder NagpalCenter for Obesity, Diabetes and Metabolism (Internal Medicine-Molecular Medicine), Wake Forest School of Medicine, Winston-Salem, NC, USA.
Rabina MainaliCenter for Obesity, Diabetes and Metabolism (Internal Medicine-Molecular Medicine), Wake Forest School of Medicine, Winston-Salem, NC, USA.
Shokouh AhmadiCenter for Obesity, Diabetes and Metabolism (Internal Medicine-Molecular Medicine), Wake Forest School of Medicine, Winston-Salem, NC, USA.
Shaohua WangCenter for Obesity, Diabetes and Metabolism (Internal Medicine-Molecular Medicine), Wake Forest School of Medicine, Winston-Salem, NC, USA.
Ria SinghCenter for Obesity, Diabetes and Metabolism (Internal Medicine-Molecular Medicine), Wake Forest School of Medicine, Winston-Salem, NC, USA.
Kylie KavanaghDepartment of Pathology (Comparative Medicine), Wake Forest School of Medicine, Winston-Salem, NC, USA.
Dalane W KitzmanGerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Almagul KushugulovaCenter for Life Sciences, NLA, Nazarbayev University, Astana, Republic of Kazakhstan.
Francesco MarottaReGenera Research and Development for Aging Interventions, and San Babila Clinic, Corso Matteotti 1/A, Milano, Italy.
Hariom YadavCenter for Obesity, Diabetes and Metabolism (Internal Medicine-Molecular Medicine), Wake Forest School of Medicine, Winston-Salem, NC, USA.

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Denise Kathryn Houston · 2002 to 2026
$36.4M
Exercise Intolerance in Older HFPEF PatientsR01AG018915 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2001 to 2019
$5.2M
Exercise Intolerance in Elderly Diastolic Heart FailureR37AG018915 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2005 to 2013
$3.4M
NIA NIH HHS P30 AG021332NIA NIH HHS R01 AG018915NIA NIH HHS R37 AG018915
6 · The paper itself

Abstract

The development of human gut microbiota begins as soon as the neonate leaves the protective environment of the uterus (or maybe

Indexed as

Agingenteric nervous systemgut dysbiosisgut permeabilityintestinal microbiotametabolic inflammationprebioticsprobiotics

Identifiers

PMID29951588
PMCPMC6004897

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.