Evidence map›Paper›PMID 29951585›Full record

ArticleAIMS biophysics2017

G protein-coupled receptors: the evolution of structural insight.

Samantha B Gacasan, Daniel L Baker, Abby L Parrill

Abstract read
In one paragraph

Article in AIMS biophysics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma.Journal of cellular and molecular medicine · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. G Protein-Coupled Receptor-Ligand Pose and Functional Class Prediction.International journal of molecular sciences · 2024
    Article
  8. Single-chain fluorescent integrators for mapping G-protein-coupled receptor agonists.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Review
  10. MUG: A mutation overview of GPCR subfamily A17 receptors.Computational and structural biotechnology journal · 2023
    Article
  11. Frontiers in endocrinology · 2023
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Samantha B GacasanDepartment of Chemistry, University of Memphis, 3744 Walker Ave, Memphis, TN 38152, USA.
Daniel L BakerDepartment of Chemistry, University of Memphis, 3744 Walker Ave, Memphis, TN 38152, USA.
Abby L ParrillDepartment of Chemistry, University of Memphis, 3744 Walker Ave, Memphis, TN 38152, USA.

Funding

GPR88 Ligand DiscoveryR15MH109034 · NIMH · UNIVERSITY OF MEMPHIS · PI PARRILL, ABBY L. · 2016 to 2016
$408k
NIMH NIH HHS R15 MH109034
6 · The paper itself

Abstract

G protein-coupled receptors (GPCR) comprise a diverse superfamily of over 800 proteins that have gained relevance as biological targets for pharmaceutical drug design. Although these receptors have been investigated for decades, three-dimensional structures of GPCR have only recently become available. In this review, we focus on the technological advancements that have facilitated efforts to gain insights into GPCR structure. Progress in these efforts began with the initial crystal structure determination of rhodopsin (PDB: 1F88) in 2000 and has continued to the most recently published structure of the A

Indexed as

7TM domainagonistsallosteric modulatorsantagonistsextracellular loopsfusion proteinsG protein-coupled receptorsintracellular loopsinverse agonistsligand bindingx-ray crystallography

Identifiers

PMID29951585
PMCPMC6018013

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.