Evidence map›Paper›PMID 29951207›Full record

ArticlePharmacology research & perspectives2018

Potential role for histone deacetylation in chronic diazepam-induced downregulation of α1-GABA

James Auta, Eleonora Gatta, John M Davis, Subhash C Pandey, Alessandro Guidotti

Open access · goldAbstract read
In one paragraph

Article in Pharmacology research & perspectives, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. GABAFrontiers in psychiatry · 2022
    Review
  7. Review
  8. Regulation of GABAInternational journal of molecular sciences · 2020
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

James AutaCenter for Alcohol Research in Epigenetics Department of Psychiatry College of Medicine University of Illinois Chicago Illinois.ORCID 0000-0002-5468-7704
Eleonora GattaCenter for Alcohol Research in Epigenetics Department of Psychiatry College of Medicine University of Illinois Chicago Illinois.
John M DavisThe Psychiatric Institute Department of Psychiatry College of Medicine University of Illinois Chicago Illinois.
Subhash C PandeyCenter for Alcohol Research in Epigenetics Department of Psychiatry College of Medicine University of Illinois Chicago Illinois.
Alessandro GuidottiCenter for Alcohol Research in Epigenetics Department of Psychiatry College of Medicine University of Illinois Chicago Illinois.
University of Illinois Urbana-Champaign · US

Funding

Pilot Project Program P50AA022538 · NIAAA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SUBHASH C. PANDEY · 2015 to 2026
$21.3M
Nicotinic receptor stimulation and epigenetic regulation of GABAergic function.R01MH093348 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GUIDOTTI, ALESSANDRO · 2011 to 2015
$1.9M
Epigenetic Markers For Development of SchizophreniaR01MH101043 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GUIDOTTI, ALESSANDRO · 2013 to 2015
$595k
NIAAA NIH HHS P50 AA022538NIMH NIH HHS R01 MH093348NIMH NIH HHS R01 MH101043
6 · The paper itself

Abstract

Corroborating evidence indicate that the downregulation of GABA

Indexed as

AcetylationAnimalsAnti-Anxiety AgentsAnticonvulsantsDiazepamDNA MethylationDown-RegulationHistone Deacetylase 1Histone Deacetylase 2HistonesMalePrefrontal CortexRats, Sprague-DawleyReceptors, GABA-AAnti-Anxiety AgentsAnticonvulsantsDiazepamHdac1 protein, ratHdac2 protein, ratHistone Deacetylase 1Histone Deacetylase 2HistonesReceptors, GABA-Adiazepamhistone deacetylationimidazenilα1 GABAA receptor subunit

Identifiers

PMID29951207
PMCPMC6019704
OpenAlexW2809821915

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.