Evidence map›Paper›PMID 29951131›Full record

ArticleClinical epigenetics2018

Type 2 diabetes and cardiometabolic risk may be associated with increase in DNA methylation of

Robin Ortiz, Joshua J Joseph, Richard Lee, Gary S Wand, Sherita Hill Golden

Open access · goldAbstract read
In one paragraph

Article in Clinical epigenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Frontiers in nutrition · 2026
    Article
  4. Review
  5. Integrated multiomic analyses: An approach to improve understanding of diabetic kidney disease.Diabetic medicine : a journal of the British Diabetic Association · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Cortisol and cardiometabolic disease: a target for advancing health equity.Trends in endocrinology and metabolism: TEM · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Robin Ortiz1Departments of Internal Medicine & Pediatrics, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Harvey Bldg. Rm 805, Baltimore, MD 21287 USA.
Joshua J Joseph2Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The Ohio State University Wexner Medical Center, 566 McCampbell Hall, 1581 Dodd Drive, Columbus, OH 43210 USA.
Richard Lee3Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Ave. Ross Bldg. 1068, Baltimore, MD 21205 USA.
Gary S Wand4Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E. Monument Street Suite 333, Baltimore, MD 21287 USA.
Sherita Hill Golden4Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E. Monument Street Suite 333, Baltimore, MD 21287 USA.ORCID 0000-0002-0957-5850
Johns Hopkins University · USThe Ohio State University Wexner Medical Center · US

Funding

Stress Effects on Alcohol Consumption: Age of onset and genes in heavy drinkersU01AA020890 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI MCCAUL, MARY E, WAND, GARY S · 2012 to 2021
$3.6M
Prevalence and Correlates of Minor Depression in Type 2 DiabetesR03DK088997 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI GOLDEN, SHERITA HILL · 2010 to 2012
$611k
NIAAA NIH HHS U01 AA020890NIDDK NIH HHS R03 DK088997
6 · The paper itself

Abstract

Background: Subclinical hypercortisolism and hypothalamic-pituitary-adrenal (HPA) axis dysfunction are associated with type 2 diabetes (T2DM), cardiovascular disease, and metabolic dysfunction. Intronic methylation of Results: Greater percent methylation of the Conclusions:

Indexed as

AgedBody Mass IndexCardiovascular DiseasesCholesterol, LDLCpG IslandsDiabetes Mellitus, Type 2DNA MethylationFemaleGlycated HemoglobinHumansHydrocortisoneIntronsMaleMiddle AgedRisk FactorsTacrolimus Binding Protein 5Cholesterol, LDLGlycated Hemoglobinhemoglobin A1c protein, humanHydrocortisoneTacrolimus Binding Protein 5Tacrolimus Binding ProteinsBody mass index (BMI)Cardiovascular diseaseCortisolDiabetesEpigeneticsFKBP5Hemoglobin A1cMethylationObesityWaist circumference

Identifiers

PMID29951131
PMCPMC6010037
OpenAlexW2808930050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.