Evidence map›Paper›PMID 29950922›Full record

ArticleJournal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology2018

Nanoparticle transport pathways into tumors.

S M Moghimi, D Simberg

Abstract read
In one paragraph

Article in Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. The Immune Microenvironment in Liver Cancer: From Analysis to Targeting.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Capsules Rheology in Carreau-Yasuda Fluids.Nanomaterials (Basel, Switzerland) · 2020
    Article
  17. Review
  18. Membrane-core nanoparticles for cancer nanomedicine.Advanced drug delivery reviews · 2020
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

S M Moghimi1School of Pharmacy, The Faculty of Medical Sciences, Newcastle University, King George VI Building, Newcastle upon Tyne, NE1 7RU UK.ORCID 0000-0003-0836-926X
D Simberg3Translational Bio-Nanosciences Laboratory and Colorado Center for Nanomedicine and Nanosafety, The Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences, University of Colorado Denver, Anschutz Medical Campus, 12850 East Montview Blvd, Aurora, CO 80045 USA.

Funding

Painted erythrocyte carriers for therapy of acute myeloid leukemiaR01CA194058 · NCI · UNIVERSITY OF COLORADO DENVER · PI SIMBERG, DMITRI · 2016 to 2020
$1.8M
The alternative complement pathway and hemocompatibility of nanosurfacesR01EB022040 · NIBIB · UNIVERSITY OF COLORADO DENVER · PI SIMBERG, DMITRI · 2016 to 2019
$1.4M
Mechanisms and barriers in nanomedicineR13EB021826 · NIBIB · UNIVERSITY OF COLORADO DENVER · PI SIMBERG, DMITRI · 2016 to 2016
$10k
NCI NIH HHS R01 CA194058NIBIB NIH HHS R01 EB022040NIBIB NIH HHS R13 EB021826
6 · The paper itself

Abstract

Two transport pathways (interendothelial and transendothelial routes) have long been proposed for entry of nanoparticles from the blood circulation into solid tumors. We examine and discuss available evidence supporting interendothelial and transendothelial transport processes and suggest new avenues for re-evaluating these pathways. Understanding of integrative mechanisms controlling nanoparticle extravasation into tumors is important for improving engineering and performance of anti-cancer nanopharmaceuticals.

Indexed as

Interendothelial transportNanomedicineNanoparticleNanoparticle accumulation in tumorsSolid tumorsTransendothelial transport

Identifiers

PMID29950922
PMCPMC6013540

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.