ArticleCancer management and research2018
An increased number of negative lymph nodes is associated with a higher immune response and longer survival in colon cancer patients.
Article in Cancer management and research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06096493 (Predictors of Disease Free Survival After Curative Cancer Rectum Surgery), which is not on this map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Predictors of Disease Free Survival After Curative Cancer Rectum Surgery
Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- The effect of the number of negative lymph nodes removed during surgery on the survival and recurrence rates of patients with breast cancer after surgery.BMC surgery · 2026Article
- Optimal number of lymph nodes for long-term survival in lymph node-negative rectal cancer: a population-based study.World journal of surgical oncology · 2025Article
- Article
- The optimal minimum lymph node count for carcinoembryonic antigen elevated colon cancer: a population-based study in the SEER set and External set.BMC cancer · 2023Article
- Metastatic lymph nodes and prognosis assessed by the number of retrieved lymph nodes in gastric cancer.World journal of gastrointestinal surgery · 2022Article
- Orexin A Suppresses the Expression of Exosomal PD-L1 in Colon Cancer and Promotes T Cell Activity by Inhibiting JAK2/STAT3 Signaling Pathway.Digestive diseases and sciences · 2022Article
- Risk factors for long-term survival in patients with ypN+ M0 rectal cancer after radical anterior resection.BMC gastroenterology · 2022Article
- Exploration of a modified stage for pN0 colon cancer patients.Scientific reports · 2022Article
- Observational
- The risk factors of local recurrence and distant metastasis on pT1/T2N0 mid-low rectal cancer after total mesorectal excision.World journal of surgical oncology · 2021Article
- Impact of examined lymph node count on staging and long-term survival of patients with node-negative stage III gastric cancer: a retrospective study using a Chinese multi-institutional registry with Surveillance, Epidemiology, and End Results (SEER) data validation.Annals of translational medicine · 2020Article
- Harvest of at least 18 lymph nodes is associated with improved survival in patients with pN0 colon cancer: a retrospective cohort study.Journal of cancer research and clinical oncology · 2020Article
- Lymph Node Ratio as a Prognostic Marker in Rectal Cancer Survival: A Systematic Review and Meta-Analysis.Cureus · 2020Article
- The Number of Negative Lymph Nodes is Positively Associated with Survival in Esophageal Squamous Cell Carcinoma Patients in China.Open medicine (Warsaw, Poland) · 2020Article
- Number of Examined Lymph Nodes as a Risk Factor for Recurrence in pT1N+ or pT2-3N0 Gastric Cancer.Cancer diagnosis & prognosisArticle
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of the present study was to examine the relationship among the number of negative lymph nodes (LNs), the local and systemic immune response, and survival in patients with colon cancer. PATIENTS AND
methodsOne thousand one hundred and fifty-seven patients with colon cancer who underwent surgery at Sun Yat-sen University Cancer Center between 2009 and 2014 were included. We examined negative LNs in relation to the local and systemic immune response, including percentage carcinoma, neutrophil and lymphocyte infiltration, Crohn's-like reaction, neutrophil to lymphocyte ratio, platelets, and C-reactive protein (CRP). Disease-free survival and overall survival were also examined. We performed subgroup analysis based on the distribution of negative LNs.
resultsAn increased number of negative LNs was associated with greater neutrophil invasion (
conclusionOur study suggests that negative LNs are indicators of the immune response and are associated with a better prognosis in patients with colon cancer.
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