Evidence map›Paper›PMID 29950831›Full record

ArticleInternational journal of nanomedicine2018

Construction of injectable, pH sensitive, antibacterial, mineralized amino acid yolk-shell microspheres for potential minimally invasive treatment of bone infection.

Zhenhua Chen, Mengen Zhao, Jie Zhang, Kang Zhou, Xiuli Ren, Xifan Mei

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zhenhua Chen *Jinzhou Medical University, Jinzhou, 121001, People's Republic of China.
Mengen Zhao *Jinzhou Medical University, Jinzhou, 121001, People's Republic of China.
Jie ZhangJinzhou Medical University, Jinzhou, 121001, People's Republic of China.
Kang ZhouJinzhou Medical University, Jinzhou, 121001, People's Republic of China.
Xiuli RenJinzhou Medical University, Jinzhou, 121001, People's Republic of China.
Xifan MeiJinzhou Medical University, Jinzhou, 121001, People's Republic of China.
Jinzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTreatment of infection within bone is difficult, and conventional surgical treatment brings intense pain to the patients physically and mentally. There is an urgent need to develop injectable nano- and/or micro-medicine for minimally invasive treatment of osteomyelitis.

methodsIn this paper, amino acid (L-lysine [Lys]) was mineralized into yolk-shell structured CaCO

resultsThe as prepared Lys encapsulated CaCO

conclusionOur results demonstrated that Lys@CaCO

Indexed as

InjectionsMicrospheresAnimalsAnti-Bacterial AgentsBone Diseases, InfectiousCalcium CarbonateCell LineCell SurvivalEgg ShellHumansHydrogen-Ion ConcentrationLysineMiceMicroscopy, Electron, ScanningMineralsOsteoblastsAnti-Bacterial AgentsCalcium CarbonateLysineMineralsdelivery vehicleL-Lysinemicro-medicineosteomyelitisoxidative stress

Identifiers

PMID29950831
PMCPMC6014387
OpenAlexW2807771804

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.