ArticleScientific reports2018
Fungal endophytes from arid areas of Andalusia: high potential sources for antifungal and antitumoral agents.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Diversity and antimicrobial potential of endophytic fungi from Egyptian desert medicinal plants.Folia microbiologica · 2026Article
- Taxonomic and phylogenetic analyses reveal two newMycoKeys · 2026Article
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- Leaf litter associated fungi from South Africa to control fungal plant pathogens.Scientific reports · 2025Article
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- Antimicrobial and antiproliferative activity of biosynthesized manganese nanocomposite with amide derivative originated by endophytic Aspergillus terreus.Microbial cell factories · 2025Article
- Antimicrobial and cytotoxic activities of natural (Z)-13-docosenamide derived fromFrontiers in cellular and infection microbiology · 2025Article
- The limitless endophytes: their role as antifungal agents against top priority pathogens.Microbial cell factories · 2024Review
- Why Are There So Few Basidiomycota and Basal Fungi as Endophytes? A Review.Journal of fungi (Basel, Switzerland) · 2024Review
- Naphthoquinone Derivatives fromMolecules (Basel, Switzerland) · 2024Article
- Diversity of fungi associated with petroglyph sites in the Negev Desert, Israel, and their potential role in bioweathering.Frontiers in fungal biology · 2024Article
- Beyond Penicillin: The Potential of Filamentous Fungi for Drug Discovery in the Age of Antibiotic Resistance.Antibiotics (Basel, Switzerland) · 2023Review
- Stimulating fungal cell wall integrity by exogenous β-glucanase to improve the production of fungal natural products.Applied microbiology and biotechnology · 2022Article
- Comoclathrin, a novel potent skin-whitening agent produced by endophytic Comoclathris strains associated with Andalusia desert plants.Scientific reports · 2022Article
- Chemical elicitation as an avenue for discovery of bioactive compounds from fungal endophytes.Frontiers in chemistry · 2022Article
- Enhancing the Discovery of Bioactive Secondary Metabolites From Fungal Endophytes Using Chemical Elicitation and Variation of Fermentation Media.Frontiers in microbiology · 2022Article
- Fungal Endophytic Community and Diversity Associated with Desert Shrubs Driven by Plant Identity and Organ Differentiation in Extremely Arid Desert Ecosystem.Journal of fungi (Basel, Switzerland) · 2021Article
- Bioprospecting of endophytic microorganisms for bioactive compounds of therapeutic importance.Archives of microbiology · 2021Review
- Marine endophytic fungal metabolites: A whole new world of pharmaceutical therapy exploration.Heliyon · 2021Review
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Native plant communities from arid areas present distinctive characteristics to survive in extreme conditions. The large number of poorly studied endemic plants represents a unique potential source for the discovery of novel fungal symbionts as well as host-specific endophytes not yet described. The addition of adsorptive polymeric resins in fungal fermentations has been seen to promote the production of new secondary metabolites and is a tool used consistently to generate new compounds with potential biological activities. A total of 349 fungal strains isolated from 63 selected plant species from arid ecosystems located in the southeast of the Iberian Peninsula, were characterized morphologically as well as based on their ITS/28S ribosomal gene sequences. The fungal community isolated was distributed among 19 orders including Basidiomycetes and Ascomycetes, being Pleosporales the most abundant order. In total, 107 different genera were identified being Neocamarosporium the genus most frequently isolated from these plants, followed by Preussia and Alternaria. Strains were grown in four different media in presence and absence of selected resins to promote chemical diversity generation of new secondary metabolites. Fermentation extracts were evaluated, looking for new antifungal activities against plant and human fungal pathogens, as well as, cytotoxic activities against the human liver cancer cell line HepG2. From the 349 isolates tested, 126 (36%) exhibited significant bioactivities including 58 strains with exclusive antifungal properties and 33 strains with exclusive activity against the HepG2 hepatocellular carcinoma cell line. After LCMS analysis, 68 known bioactive secondary metabolites could be identified as produced by 96 strains, and 12 likely unknown compounds were found in a subset of 14 fungal endophytes. The chemical profiles of the differential expression of induced activities were compared. As proof of concept, ten active secondary metabolites only produced in the presence of resins were purified and identified. The structures of three of these compounds were new and herein are elucidated.
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