ArticleActa pharmacologica Sinica2018
Veratridine modifies the gating of human voltage-gated sodium channel Nav1.7.
Article in Acta pharmacologica Sinica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Discovery of NaJournal of natural products · 2025Article
- Poneratoxin as a key tool for investigating the relationship between sodium channel hypersensitivity and impaired nerve cell function.Scientific reports · 2025Article
- A High-Throughput Biosensing Approach for Rapid Screening of Compounds Targeting the hNav1.1 Channel: Marine Toxins as a Case Study.Marine drugs · 2025Article
- Veratridine-Induced Oscillations in Nav 1.7 but Not Nav 1.5 Sodium Channels Are Revealed by Membrane Potential Sensitive Dye.Membranes · 2025Article
- Identification of biomarkers for the diagnosis in colorectal polyps and metabolic dysfunction-associated steatohepatitis (MASH) by bioinformatics analysis and machine learning.Scientific reports · 2024Article
- Divergent syntheses of complex Veratrum alkaloids.Nature communications · 2024Article
- Therapeutic targeting of voltage-gated sodium channel NaFrontiers in pharmacology · 2024Review
- Effective Modulation by Lacosamide on Cumulative Inhibition ofInternational journal of molecular sciences · 2022Article
- Glycogen Synthase Kinase 3: Ion Channels, Plasticity, and Diseases.International journal of molecular sciences · 2022Review
- Diversity in Chemical Structures and Biological Properties of Plant Alkaloids.Molecules (Basel, Switzerland) · 2021Review
- Human neuronal signaling and communication assays to assess functional neurotoxicity.Archives of toxicology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Veratridine is a lipid-soluble neurotoxin derived from plants in the family Liliaceae. It has been broadly investigated for its action as a sodium channel agonist. However, the effects of veratridine on subtypes of sodium channels, especially Nav1.7, remain to be studied. Here, we investigated the effects of veratridine on human Nav1.7 ectopically expressed in HEK293A cells and recorded Nav1.7 currents from the cells using whole-cell patch clamp technique. We found that veratridine exerted a dose-dependent inhibitory effect on the peak current of Nav1.7, with the half-maximal inhibition concentration (IC
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