Evidence map›Paper›PMID 29950608›Full record

ArticleScientific reports2018

Maternal Vitamin D Prevents Abnormal Dopaminergic Development and Function in a Mouse Model of Prenatal Immune Activation.

Wei Luan, Luke Alexander Hammond, Stephanie Vuillermot, Urs Meyer, Darryl Walter Eyles

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Vitamin D and schizophrenia: 20 years on.Molecular psychiatry · 2021
    Pooled it
  2. Pooled it
  3. Trial
  4. A head start: The relationship of placental factors to craniofacial and brain development.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Article
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  10. Developmental Manipulation-Induced Changes in Cognitive Functioning.Current topics in behavioral neurosciences · 2023
    Article
  11. Review
  12. Review
  13. Article
  14. Advantages and Limitations of Animal Schizophrenia Models.International journal of molecular sciences · 2022
    Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Transgenerational modification of dopaminergic dysfunctions induced by maternal immune activation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Wei LuanQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
Luke Alexander HammondZuckerman Mind Brain Behavior Institute, Columbia University, New York, New York, USA.
Stephanie VuillermotPhysiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland.
Urs MeyerInstitute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland.ORCID 0000-0001-7244-0345
Darryl Walter EylesQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia. eyles@uq.edu.au.
The University of Queensland · AUColumbia University · USETH Zurich · CHUniversity of Zurich · CH

Funding

Department of Health | National Health and Medical Research Council (NHMRC) APP 1057883Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030_169544
6 · The paper itself

Abstract

Dysfunction in dopamine (DA) systems is a prominent feature in schizophrenia patients and may result from the abnormal development of mesencephalic (mes)DA systems. Maternal immune activation (MIA) and developmental vitamin D (DVD)-deficiency both induce schizophrenia-relevant dopaminergic abnormalities in adult offspring. In this study, we investigated whether maternal administration of the vitamin D hormone (1,25OHD, VIT

Indexed as

AmphetamineAnimalsBehavior, AnimalDisease Models, AnimalDopaminergic NeuronsFemaleGestational AgeImmunohistochemistryLocomotionMaleMiceMice, Inbred C57BLPoly I-CPregnancyVitamin DAmphetaminePoly I-CVitamin D

Identifiers

PMID29950608
PMCPMC6021387
OpenAlexW2809022517

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.