Evidence map›Paper›PMID 29950603›Full record

ArticleScientific reports2018

The pharmacological perturbation of brain zinc impairs BDNF-related signaling and the cognitive performances of young mice.

Valerio Frazzini, Alberto Granzotto, Manuela Bomba, Noemi Massetti, Vanessa Castelli, Marco d'Aurora, Miriam Punzi, Mariangela Iorio, Alessandra Mosca, Stefano Delli Pizzi and 3 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  4. Review
  5. Article
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  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Genetic removal of synaptic ZnFrontiers in neurology · 2022
    Article
  13. Article
  14. Article
  15. Zinc Status Alters Alzheimer's Disease Progression through NLRP3-Dependent Inflammation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  16. Neurobiology of zinc and its role in neurogenesis.European journal of nutrition · 2021
    Review
  17. Article
  18. A NeurotoxicFrontiers in molecular neuroscience · 2020
    Review
  19. Review
  20. Inhibition ofAging · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Valerio FrazziniCenter of Excellence on Aging and Translational Medicine - CeSI-MeT, Chieti, Italy.
Alberto GranzottoCenter of Excellence on Aging and Translational Medicine - CeSI-MeT, Chieti, Italy.ORCID 0000-0001-9181-4373
Manuela BombaCenter of Excellence on Aging and Translational Medicine - CeSI-MeT, Chieti, Italy.
Noemi MassettiCenter of Excellence on Aging and Translational Medicine - CeSI-MeT, Chieti, Italy.
Vanessa CastelliDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.ORCID 0000-0001-5054-4717
Marco d'AuroraCenter of Excellence on Aging and Translational Medicine - CeSI-MeT, Chieti, Italy.
Miriam PunziCenter of Excellence on Aging and Translational Medicine - CeSI-MeT, Chieti, Italy.
Mariangela IorioCenter of Excellence on Aging and Translational Medicine - CeSI-MeT, Chieti, Italy.
Alessandra MoscaCenter of Excellence on Aging and Translational Medicine - CeSI-MeT, Chieti, Italy.
Stefano Delli PizziCenter of Excellence on Aging and Translational Medicine - CeSI-MeT, Chieti, Italy.ORCID 0000-0003-4075-0132
Valentina GattaCenter of Excellence on Aging and Translational Medicine - CeSI-MeT, Chieti, Italy.
Annamaria CiminiDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Stefano L SensiCenter of Excellence on Aging and Translational Medicine - CeSI-MeT, Chieti, Italy. ssensi@uci.edu.ORCID 0000-0002-0710-2574
University of Chieti-Pescara · ITCentre National de la Recherche Scientifique · FRIstituto Nazionale di Fisica Nucleare · ITUniversity of California, Irvine · USUniversity of L'Aquila · IT

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) PRIN 2011; 2010M2JARJ_005Ministero della Salute (Ministry of Health, Italy) NET-2011-02346784-1Ministero della Salute (Ministry of Health, Italy) RF-2013–02358785
6 · The paper itself

Abstract

Zinc (Zn

Indexed as

AnimalsBrainBrain-Derived Neurotrophic FactorClioquinolCognitionMaleMiceMice, Inbred C57BLNeuronal PlasticitySignal TransductionZincBrain-Derived Neurotrophic FactorClioquinolZinc

Identifiers

PMID29950603
PMCPMC6021411
OpenAlexW2950045154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.