ArticleScientific reports2018
BALB/c mice infected with DENV-2 strain 66985 by the intravenous route display injury in the central nervous system.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- Histopathological Alterations and Dysregulation of Type I Interferon Signaling in the Human Cerebral Cortex During Severe Dengue.Journal of medical virology · 2025Article
- Repurposing Neurological Drugs Against Dengue Virus Infection.Journal of tropical medicine · 2025Review
- Primary infection of BALB/c mice with a dengue virus type 4 strain leads to kidney injury.Memorias do Instituto Oswaldo Cruz · 2023Article
- Suppression of TGF-β/Smad2 signaling by GW788388 enhances DENV-2 clearance in macrophages.Journal of medical virology · 2022Article
- Evaluating Dengue Virus Pathogenesis in Mice and Humans by Histological and Immunohistochemistry Approaches.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Immunocompetent Mice Infected by Two Lineages of Dengue Virus Type 2: Observations on the Pathology of the Lung, Heart and Skeletal Muscle.Microorganisms · 2021Article
- Brazilian Dengue Virus Type 2-Associated Renal Involvement in a Murine Model: Outcomes after Infection by Two Lineages of the Asian/American Genotype.Pathogens (Basel, Switzerland) · 2021Article
- Viral and Prion Infections Associated with Central Nervous System Syndromes in Brazil.Viruses · 2021Review
- Comparative analysis of liver involvement caused by two DENV-2 lineages using an immunocompetent murine model.Scientific reports · 2021Article
- Crocetin Improves Dengue Virus-Induced Liver Injury.Viruses · 2020Article
- Article
- Dengue infection in mice inoculated by the intracerebral route: neuropathological effects and identification of target cells for virus replication.Scientific reports · 2019Article
- Flaviviruses as agents of childhood central nervous system infections in Brazil.New microbes and new infections · 2019Review
- Flaviviruses as agents of childhood central nervous system infections in Brazil.New microbes and new infections · 2019Article
- Dengue Virus Infection of Blood-Brain Barrier Cells: Consequences of Severe Disease.Frontiers in microbiology · 2019Review
- Signaling of Macrophage Inflammatory Protein (MIP)-3β Facilitates Dengue Virus-Induced Microglial Cell Migration.Viruses · 2018Article
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Authors and funding
19 authors at 5 institutions in 1 country.
Funding
Abstract
Dengue is a mild flu-like arboviral illness caused by dengue virus (DENV) that occurs in tropical and subtropical countries. An increasing number of reports have been indicating that dengue is also associated to neurological manifestations, however, little is known regarding the neuropathogenesis of the disease. Here, using BALB/c mice intravenously infected with DENV-2 strain 66985, we demonstrated that the virus is capable of invading and damaging the host's central nervous system (CNS). Brain and cerebellum of infected animals revealed histological alterations such as the presence of inflammatory infiltrates, thickening of pia matter and disorganization of white matter. Additionally, it was also seen that infection lead to altered morphology of neuroglial cells and apoptotic cell death. Such observations highlighted possible alterations that DENV may promote in the host's CNS during a natural infection, hence, helping us to better understand the neuropathological component of the disease.
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