Evidence map›Paper›PMID 29950524›Full record

ArticleThe Journal of biological chemistry2018

Uncovering the molecular mechanisms behind disease-associated leptin variants.

Ellinor Haglund, Lannie Nguyen, Nicholas Peter Schafer, Heiko Lammert, Patricia Ann Jennings, José Nelson Onuchic

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Theta-curves in proteins.Protein science : a publication of the Protein Society · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ellinor HaglundCenter for Theoretical Biological Physics, and Biosciences, Rice University, Houston, Texas 77005. Electronic address: ellinorh@rice.edu.
Lannie NguyenDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093.
Nicholas Peter SchaferCenter for Theoretical Biological Physics, and Biosciences, Rice University, Houston, Texas 77005.
Heiko LammertCenter for Theoretical Biological Physics, and Biosciences, Rice University, Houston, Texas 77005.
Patricia Ann JenningsDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093. Electronic address: pajennings@ucsd.edu.
José Nelson OnuchicCenter for Theoretical Biological Physics, and Biosciences, Rice University, Houston, Texas 77005; Departments of Physics and Astronomy, Chemistry, and Biosciences, Rice University, Houston, Texas 77005. Electronic address: jonuchic@rice.edu.
Center for Theoretical Biological Physics · USUniversity of California San Diego · US

Funding

ZWITTERION SURFACTANT DDMAB FOR IMPROV STABIL OF PROTEINP41RR001209 · NCRR · STANFORD UNIVERSITY · PI SCOTT, EMILY E · 1985 to 2011
$38.9M
Project# 4: INTERACTIONS OF ANCHORING PROTEINS WITH THEIR TARGETSP01DK054441 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TAYLOR, SUSAN S. · 1999 to 2017
$27.3M
CONCEPTUAL ASPECTS OF THE PROTEIN FOLDING PROBLEMR01GM044557 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI WOLYNES, PETER GUY · 1990 to 2018
$4.2M
Investigation of the Functional/Folding Landscapes of the Il-1 FamilyR01GM054038 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JENNINGS, PATRICIA A · 2002 to 2010
$2.4M
The New Family of NEET Proteins: 2Fe-2S Protein Mediated Health and DiseaseR01GM101467 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JENNINGS, PATRICIA A · 2012 to 2015
$1.3M
ACQUISITION OF A 500 MHZ NMR CONSOLES10RR020874 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JENNINGS, PATRICIA A · 2006 to 2006
$353k
FOLDING MECHANISM OF A BETA PROTEINR29GM054038 · NIGMS · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI JENNINGS, PATRICIA A · 1996 to 2000
$106k
HTS for Modulators of MitoNEET Proteins' FunctionR03DA034597 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JENNINGS, PATRICIA A · 2012 to 2013
$76k
NCRR NIH HHS P41 RR001209NCRR NIH HHS S10 RR020874NIDA NIH HHS R03 DA034597NIDDK NIH HHS P01 DK054441NIGMS NIH HHS R01 GM044557NIGMS NIH HHS R01 GM054038NIGMS NIH HHS R01 GM101467NIGMS NIH HHS R29 GM054038
6 · The paper itself

Abstract

The pleiotropic hormone leptin has a pivotal role in regulating energy balance by inhibiting hunger and increasing energy expenditure. Homozygous mutations found in the leptin gene are associated with extreme obesity, marked hyperphagia, and impaired immune function. Although these mutations have been characterized

Indexed as

MutationHumansLeptinMagnetic Resonance SpectroscopyProtein StabilityLEP protein, humanLeptinBioinactive hormoneCongenital-leptin DeficiencyleptinobesityPierced Lasso Topologyprotein foldingprotein misfoldingprotein structure

Identifiers

PMID29950524
PMCPMC6102133
OpenAlexW2811161480

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.