ArticleJournal of the Royal Society, Interface2018
Induction of zonal-specific cellular morphology and matrix synthesis for biomimetic cartilage regeneration using hybrid scaffolds.
Article in Journal of the Royal Society, Interface, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Topographical design principles for osteochondral tissue engineering.Bioactive materials · 2026Review
- Bioprinting of Microtissues Within Mechanically Tunable Support Baths to Engineer Anisotropic Musculoskeletal Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Zone-inspired hydrogel constructs promote spatially controlled chondrogenesis for osteochondral regeneration.Scientific reports · 2025Article
- Nanofibrous scaffolds for bone and cartilage regeneration.Applied physics reviews · 2025Article
- Advancements in hydrogel design for articular cartilage regeneration: A comprehensive review.Bioactive materials · 2025Review
- Interfacial Tissue Regeneration with Bone.Current osteoporosis reports · 2024Review
- Fabricating orientated nanofibrous meshes with a bespoke ultra-cost-effective electrospinning machine.HardwareX · 2023Article
- Biomimetic approach to articular cartilage tissue engineering using carbon nanotube-coated and textured polydimethylsiloxane scaffolds.Annals of the New York Academy of Sciences · 2022Article
- Article
- Designing an Integrated Low-cost Electrospinning Device for Nanofibrous Scaffold Fabrication.HardwareX · 2022Article
- Maintenance and Acceleration of Pericellular Matrix Formation within 3D Cartilage Cell Culture Models.Cartilage · 2021Article
- Isotropic and Anisotropic Scaffolds for Tissue Engineering: Collagen, Conventional, and Textile Fabrication Technologies and Properties.International journal of molecular sciences · 2021Review
- Advances and prospects in biomimetic multilayered scaffolds for articular cartilage regeneration.Regenerative biomaterials · 2020Review
- Differential Production of Cartilage ECM in 3D Agarose Constructs by Equine Articular Cartilage Progenitor Cells and Mesenchymal Stromal Cells.International journal of molecular sciences · 2020Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cartilage is anisotropic in nature and organized into distinct zones. Our goal was to develop zonal-specific three-dimensional hybrid scaffolds which could induce the generation of zonal-specific cellular morphology and extracellular matrix (ECM) composition. The superficial and middle zones comprised two layers of hyaluronic acid (HA) hydrogel which enveloped specifically orientated or randomly arranged polylactic acid nanofibre meshes. The deep zone comprised a HA hydrogel with multiple vertical channels. Primary bovine chondrocytes were seeded into the individual zonal scaffolds, cultured for 14 days and then the ECM was analysed. The aligned nanofibre mesh used in the superficial zone induced an elongated cell morphology, lower glycosaminoglycan (GAG) and collagen II production, and higher cell proliferation and collagen I production than the cells in the middle zone scaffold. Within the middle zone scaffold, which comprised a randomly orientated nanofibre mesh, the cells were clustered and expressed more collagen II. The deep zone scaffold induced the highest GAG production, the lowest cell proliferation and the lowest collagen I expression of the three zones. Assembling the three zones and stabilizing the arrangement with a HA hydrogel generated aligned, randomly aggregated and columnar cells in the superficial, middle and deep zones. This study presents a method to induce zonal-specific chondrocyte morphology and ECM production.
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