Evidence map›Paper›PMID 29950489›Full record

ArticleBMJ (Clinical research ed.)2018

Risk of meticillin resistant

Kimberly G Blumenthal, Na Lu, Yuqing Zhang, Yu Li, Rochelle P Walensky, Hyon K Choi

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in BMJ (Clinical research ed.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05464615 (Geisinger Antibiotic Allergy Pilot Program), which is not on this map. Cited by 181 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
181citing papers in PubMed, 6 pooled it
20.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05464615 early_phase1terminatednot on this mapstarted 2024, after this paper: background citation

Geisinger Antibiotic Allergy Pilot Program: Assess and Address (GAAP) Penicillin Allergy De-labeling in Inpatient Setting by Performing Direct Oral Amoxicillin Challenge in Low-risk Patients

TypeinterventionalSponsorGeisinger ClinicRan2024 to 2026Enrolled20ConditionsPenicillin AllergyArmsAmoxicillin
3 · Its place in the literature

Who cites it

181 citing papers in PubMed, 6 syntheses or guidelines pooled it, 338 citations in OpenAlex.

  1. Pooled it
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  5. Sexually Transmitted Infections Treatment Guidelines, 2021.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2021
    Guideline
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  20. Direct Oral Challenge for Penicillin Allergy: The International Network of Antibiotic Allergy Nations (iNAAN) Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Observational

121 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kimberly G BlumenthalDivision of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA 20114, USA kblumenthal1@partners.org.
Na LuDivision of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA 20114, USA.
Yuqing ZhangDivision of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA 20114, USA.
Yu LiDivision of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA 20114, USA.
Rochelle P WalenskyMedical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA.
Hyon K ChoiDivision of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA 20114, USA.
Massachusetts General Hospital · USHarvard University · US

Funding

The Clinical and Economic Impact of Penicillin AllergyK01AI125631 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI BLUMENTHAL, KIMBERLY GOLD · 2016 to 2021
$779k
NIAID NIH HHS K01 AI125631
6 · The paper itself

Abstract

objectiveTo evaluate the relation between penicillin allergy and development of meticillin resistant

designPopulation based matched cohort study.

settingUnited Kingdom general practice (1995-2015).

participants301 399 adults without previous MRSA or

main outcome measuresThe primary outcome was risk of incident MRSA and

resultsAmong 64 141 adults with penicillin allergy and 237 258 matched comparators, 1365 developed MRSA (442 participants with penicillin allergy and 923 comparators) and 1688 developed

conclusionsDocumented penicillin allergy was associated with an increased risk of MRSA and

Indexed as

Clostridioides difficileMethicillin-Resistant Staphylococcus aureusAdultAgedClostridium InfectionsCohort StudiesDrug HypersensitivityFemaleHumansIncidenceMaleMiddle AgedPenicillinsStaphylococcal InfectionsUnited KingdomPenicillins

Identifiers

PMID29950489
PMCPMC6019853
OpenAlexW2810697168

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.