ArticleNeurology2018
Independent home use of a brain-computer interface by people with amyotrophic lateral sclerosis.
2 registry-linked trialsAbstract read
In one paragraph
Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 51 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cognixion ALS BCI Longitudinal Study
Cognixion Pass Through Study
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of research on augmentative and alternative communication brain-computer interface systems for individuals with disabilities.Frontiers in human neuroscience · 2022Pooled it
- On the way home: a BCI-FES hand therapy self-managed by sub-acute SCI participants and their caregivers: a usability study.Journal of neuroengineering and rehabilitation · 2021Trial
- Multimodal Assessment of Consciousness with Brain-Computer Interfaces and Artificial Intelligence: From Acquired Brain Injury to Neurodegenerative Disease.Journal of clinical medicine · 2026Review
- Brain-computer interface: an update for the clinicians.Frontiers in human neuroscience · 2026Review
- Individualized electrode subset improves the calibration accuracy of an EEG P300-design brain-computer interface for people with severe cerebral palsy.Frontiers in human neuroscience · 2026Article
- Current status and future prospects of brain-computer interfaces in the field of neurological disease rehabilitation.Frontiers in rehabilitation sciences · 2026Review
- Innovation, Adaptation, and Human Dignity in Assistive Robotics in Amyotrophic Lateral Sclerosis: A Rehabilitation Medicine Perspective.Journal of biotechnology and biomedicine · 2026Article
- Disorder of consciousness rather than complete Locked-In Syndrome for end stage Amyotrophic Lateral Sclerosis: a case series.Communications medicine · 2025Article
- Making brain-computer interfaces as reliable as muscles.Journal of neural engineering · 2025Review
- [Performance evaluation of a wearable steady-state visual evoked potential based brain-computer interface in real-life scenario].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Article
- Article
- Advancements in the application of brain-computer interfaces based on different paradigms in amyotrophic lateral sclerosis.Frontiers in neuroscience · 2025Review
- Postmovement Beta Rebound in Real and Imagined Movement.Motor control · 2025Article
- Making Video Games More Inclusive for People Living With Motor Neuron Disease: Scoping Review.JMIR rehabilitation and assistive technologies · 2024Article
- A review of ethical considerations for the medical applications of brain-computer interfaces.Cognitive neurodynamics · 2024Review
- A review on the performance of brain-computer interface systems used for patients with locked-in and completely locked-in syndrome.Cognitive neurodynamics · 2024Review
- Brain-Computer Interfaces, Completely Locked-In State in Neurodegenerative Diseases, and End-of-Life Decisions.Journal of bioethical inquiry · 2024Article
- Review
- Applications of brain-computer interfaces in neurodegenerative diseases.Neurosurgical review · 2023Review
- Can vibrotactile stimulation and tDCS help inefficient BCI users?Journal of neuroengineering and rehabilitation · 2023Article
Corrections and comments
- Commented on by
Authors and funding
20 authors.
Jonathan R WolpawFrom the Department of Neurology (J.R.W., D.S.H.), Albany Stratton Veterans Affairs Medical Center; Wadsworth Center (J.R.W., T.M.V., S.M.H., L.M.M., C.S.C., S.W., D.J.M., E.W.S.), National Center for Adaptive Neurotechnologies, New York State Department of Health, Albany; Durham Veterans Affairs Medical Center (R.S.B.) and Department of Neurology (R.S.B.), Duke University School of Medicine, NC; Veterans Affairs Cooperative Studies Program Coordinating Center (D.J.R., H.S., T.P.), Hines VA Medical Center, IL; Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center (R.J.R.) and University of New Mexico College of Pharmacy; Department of Neurology (P.G.B.), Louis Stokes Cleveland Veterans Affairs Medical Center, OH; Providence Veterans Affairs Medical Center (A.C.L.) and Department of Neurology, Brown University, RI; Veterans Affairs Connecticut Healthcare System (H.S.P.) and Department of Neurology, Yale School of Medicine, New Haven, CT; Department of Communication Science and Disorders (K.J.H.), University of Pittsburgh, PA; Cooperative Studies Program Central Office (D.G.H.), Department of Veterans Affairs Office of Research & Development, Washington, DC; and Louis Stokes Cleveland Veterans Affairs Medical Center (R.L.R.) and Department of Neurology, Case Western Reserve University School of Medicine, OH. jonathan.wolpaw@health.ny.gov.
Richard S BedlackFrom the Department of Neurology (J.R.W., D.S.H.), Albany Stratton Veterans Affairs Medical Center; Wadsworth Center (J.R.W., T.M.V., S.M.H., L.M.M., C.S.C., S.W., D.J.M., E.W.S.), National Center for Adaptive Neurotechnologies, New York State Department of Health, Albany; Durham Veterans Affairs Medical Center (R.S.B.) and Department of Neurology (R.S.B.), Duke University School of Medicine, NC; Veterans Affairs Cooperative Studies Program Coordinating Center (D.J.R., H.S., T.P.), Hines VA Medical Center, IL; Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center (R.J.R.) and University of New Mexico College of Pharmacy; Department of Neurology (P.G.B.), Louis Stokes Cleveland Veterans Affairs Medical Center, OH; Providence Veterans Affairs Medical Center (A.C.L.) and Department of Neurology, Brown University, RI; Veterans Affairs Connecticut Healthcare System (H.S.P.) and Department of Neurology, Yale School of Medicine, New Haven, CT; Department of Communication Science and Disorders (K.J.H.), University of Pittsburgh, PA; Cooperative Studies Program Central Office (D.G.H.), Department of Veterans Affairs Office of Research & Development, Washington, DC; and Louis Stokes Cleveland Veterans Affairs Medical Center (R.L.R.) and Department of Neurology, Case Western Reserve University School of Medicine, OH.
Domenic J RedaFrom the Department of Neurology (J.R.W., D.S.H.), Albany Stratton Veterans Affairs Medical Center; Wadsworth Center (J.R.W., T.M.V., S.M.H., L.M.M., C.S.C., S.W., D.J.M., E.W.S.), National Center for Adaptive Neurotechnologies, New York State Department of Health, Albany; Durham Veterans Affairs Medical Center (R.S.B.) and Department of Neurology (R.S.B.), Duke University School of Medicine, NC; Veterans Affairs Cooperative Studies Program Coordinating Center (D.J.R., H.S., T.P.), Hines VA Medical Center, IL; Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center (R.J.R.) and University of New Mexico College of Pharmacy; Department of Neurology (P.G.B.), Louis Stokes Cleveland Veterans Affairs Medical Center, OH; Providence Veterans Affairs Medical Center (A.C.L.) and Department of Neurology, Brown University, RI; Veterans Affairs Connecticut Healthcare System (H.S.P.) and Department of Neurology, Yale School of Medicine, New Haven, CT; Department of Communication Science and Disorders (K.J.H.), University of Pittsburgh, PA; Cooperative Studies Program Central Office (D.G.H.), Department of Veterans Affairs Office of Research & Development, Washington, DC; and Louis Stokes Cleveland Veterans Affairs Medical Center (R.L.R.) and Department of Neurology, Case Western Reserve University School of Medicine, OH.
Robert J RingerFrom the Department of Neurology (J.R.W., D.S.H.), Albany Stratton Veterans Affairs Medical Center; Wadsworth Center (J.R.W., T.M.V., S.M.H., L.M.M., C.S.C., S.W., D.J.M., E.W.S.), National Center for Adaptive Neurotechnologies, New York State Department of Health, Albany; Durham Veterans Affairs Medical Center (R.S.B.) and Department of Neurology (R.S.B.), Duke University School of Medicine, NC; Veterans Affairs Cooperative Studies Program Coordinating Center (D.J.R., H.S., T.P.), Hines VA Medical Center, IL; Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center (R.J.R.) and University of New Mexico College of Pharmacy; Department of Neurology (P.G.B.), Louis Stokes Cleveland Veterans Affairs Medical Center, OH; Providence Veterans Affairs Medical Center (A.C.L.) and Department of Neurology, Brown University, RI; Veterans Affairs Connecticut Healthcare System (H.S.P.) and Department of Neurology, Yale School of Medicine, New Haven, CT; Department of Communication Science and Disorders (K.J.H.), University of Pittsburgh, PA; Cooperative Studies Program Central Office (D.G.H.), Department of Veterans Affairs Office of Research & Development, Washington, DC; and Louis Stokes Cleveland Veterans Affairs Medical Center (R.L.R.) and Department of Neurology, Case Western Reserve University School of Medicine, OH.
Patricia G BanksFrom the Department of Neurology (J.R.W., D.S.H.), Albany Stratton Veterans Affairs Medical Center; Wadsworth Center (J.R.W., T.M.V., S.M.H., L.M.M., C.S.C., S.W., D.J.M., E.W.S.), National Center for Adaptive Neurotechnologies, New York State Department of Health, Albany; Durham Veterans Affairs Medical Center (R.S.B.) and Department of Neurology (R.S.B.), Duke University School of Medicine, NC; Veterans Affairs Cooperative Studies Program Coordinating Center (D.J.R., H.S., T.P.), Hines VA Medical Center, IL; Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center (R.J.R.) and University of New Mexico College of Pharmacy; Department of Neurology (P.G.B.), Louis Stokes Cleveland Veterans Affairs Medical Center, OH; Providence Veterans Affairs Medical Center (A.C.L.) and Department of Neurology, Brown University, RI; Veterans Affairs Connecticut Healthcare System (H.S.P.) and Department of Neurology, Yale School of Medicine, New Haven, CT; Department of Communication Science and Disorders (K.J.H.), University of Pittsburgh, PA; Cooperative Studies Program Central Office (D.G.H.), Department of Veterans Affairs Office of Research & Development, Washington, DC; and Louis Stokes Cleveland Veterans Affairs Medical Center (R.L.R.) and Department of Neurology, Case Western Reserve University School of Medicine, OH.
Theresa M VaughanFrom the Department of Neurology (J.R.W., D.S.H.), Albany Stratton Veterans Affairs Medical Center; Wadsworth Center (J.R.W., T.M.V., S.M.H., L.M.M., C.S.C., S.W., D.J.M., E.W.S.), National Center for Adaptive Neurotechnologies, New York State Department of Health, Albany; Durham Veterans Affairs Medical Center (R.S.B.) and Department of Neurology (R.S.B.), Duke University School of Medicine, NC; Veterans Affairs Cooperative Studies Program Coordinating Center (D.J.R., H.S., T.P.), Hines VA Medical Center, IL; Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center (R.J.R.) and University of New Mexico College of Pharmacy; Department of Neurology (P.G.B.), Louis Stokes Cleveland Veterans Affairs Medical Center, OH; Providence Veterans Affairs Medical Center (A.C.L.) and Department of Neurology, Brown University, RI; Veterans Affairs Connecticut Healthcare System (H.S.P.) and Department of Neurology, Yale School of Medicine, New Haven, CT; Department of Communication Science and Disorders (K.J.H.), University of Pittsburgh, PA; Cooperative Studies Program Central Office (D.G.H.), Department of Veterans Affairs Office of Research & Development, Washington, DC; and Louis Stokes Cleveland Veterans Affairs Medical Center (R.L.R.) and Department of Neurology, Case Western Reserve University School of Medicine, OH.
Susan M HeckmanFrom the Department of Neurology (J.R.W., D.S.H.), Albany Stratton Veterans Affairs Medical Center; Wadsworth Center (J.R.W., T.M.V., S.M.H., L.M.M., C.S.C., S.W., D.J.M., E.W.S.), National Center for Adaptive Neurotechnologies, New York State Department of Health, Albany; Durham Veterans Affairs Medical Center (R.S.B.) and Department of Neurology (R.S.B.), Duke University School of Medicine, NC; Veterans Affairs Cooperative Studies Program Coordinating Center (D.J.R., H.S., T.P.), Hines VA Medical Center, IL; Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center (R.J.R.) and University of New Mexico College of Pharmacy; Department of Neurology (P.G.B.), Louis Stokes Cleveland Veterans Affairs Medical Center, OH; Providence Veterans Affairs Medical Center (A.C.L.) and Department of Neurology, Brown University, RI; Veterans Affairs Connecticut Healthcare System (H.S.P.) and Department of Neurology, Yale School of Medicine, New Haven, CT; Department of Communication Science and Disorders (K.J.H.), University of Pittsburgh, PA; Cooperative Studies Program Central Office (D.G.H.), Department of Veterans Affairs Office of Research & Development, Washington, DC; and Louis Stokes Cleveland Veterans Affairs Medical Center (R.L.R.) and Department of Neurology, Case Western Reserve University School of Medicine, OH.
Lynn M McCaneFrom the Department of Neurology (J.R.W., D.S.H.), Albany Stratton Veterans Affairs Medical Center; Wadsworth Center (J.R.W., T.M.V., S.M.H., L.M.M., C.S.C., S.W., D.J.M., E.W.S.), National Center for Adaptive Neurotechnologies, New York State Department of Health, Albany; Durham Veterans Affairs Medical Center (R.S.B.) and Department of Neurology (R.S.B.), Duke University School of Medicine, NC; Veterans Affairs Cooperative Studies Program Coordinating Center (D.J.R., H.S., T.P.), Hines VA Medical Center, IL; Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center (R.J.R.) and University of New Mexico College of Pharmacy; Department of Neurology (P.G.B.), Louis Stokes Cleveland Veterans Affairs Medical Center, OH; Providence Veterans Affairs Medical Center (A.C.L.) and Department of Neurology, Brown University, RI; Veterans Affairs Connecticut Healthcare System (H.S.P.) and Department of Neurology, Yale School of Medicine, New Haven, CT; Department of Communication Science and Disorders (K.J.H.), University of Pittsburgh, PA; Cooperative Studies Program Central Office (D.G.H.), Department of Veterans Affairs Office of Research & Development, Washington, DC; and Louis Stokes Cleveland Veterans Affairs Medical Center (R.L.R.) and Department of Neurology, Case Western Reserve University School of Medicine, OH.
Charles S CarmackFrom the Department of Neurology (J.R.W., D.S.H.), Albany Stratton Veterans Affairs Medical Center; Wadsworth Center (J.R.W., T.M.V., S.M.H., L.M.M., C.S.C., S.W., D.J.M., E.W.S.), National Center for Adaptive Neurotechnologies, New York State Department of Health, Albany; Durham Veterans Affairs Medical Center (R.S.B.) and Department of Neurology (R.S.B.), Duke University School of Medicine, NC; Veterans Affairs Cooperative Studies Program Coordinating Center (D.J.R., H.S., T.P.), Hines VA Medical Center, IL; Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center (R.J.R.) and University of New Mexico College of Pharmacy; Department of Neurology (P.G.B.), Louis Stokes Cleveland Veterans Affairs Medical Center, OH; Providence Veterans Affairs Medical Center (A.C.L.) and Department of Neurology, Brown University, RI; Veterans Affairs Connecticut Healthcare System (H.S.P.) and Department of Neurology, Yale School of Medicine, New Haven, CT; Department of Communication Science and Disorders (K.J.H.), University of Pittsburgh, PA; Cooperative Studies Program Central Office (D.G.H.), Department of Veterans Affairs Office of Research & Development, Washington, DC; and Louis Stokes Cleveland Veterans Affairs Medical Center (R.L.R.) and Department of Neurology, Case Western Reserve University School of Medicine, OH.
Stefan WindenFrom the Department of Neurology (J.R.W., D.S.H.), Albany Stratton Veterans Affairs Medical Center; Wadsworth Center (J.R.W., T.M.V., S.M.H., L.M.M., C.S.C., S.W., D.J.M., E.W.S.), National Center for Adaptive Neurotechnologies, New York State Department of Health, Albany; Durham Veterans Affairs Medical Center (R.S.B.) and Department of Neurology (R.S.B.), Duke University School of Medicine, NC; Veterans Affairs Cooperative Studies Program Coordinating Center (D.J.R., H.S., T.P.), Hines VA Medical Center, IL; Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center (R.J.R.) and University of New Mexico College of Pharmacy; Department of Neurology (P.G.B.), Louis Stokes Cleveland Veterans Affairs Medical Center, OH; Providence Veterans Affairs Medical Center (A.C.L.) and Department of Neurology, Brown University, RI; Veterans Affairs Connecticut Healthcare System (H.S.P.) and Department of Neurology, Yale School of Medicine, New Haven, CT; Department of Communication Science and Disorders (K.J.H.), University of Pittsburgh, PA; Cooperative Studies Program Central Office (D.G.H.), Department of Veterans Affairs Office of Research & Development, Washington, DC; and Louis Stokes Cleveland Veterans Affairs Medical Center (R.L.R.) and Department of Neurology, Case Western Reserve University School of Medicine, OH.
Dennis J McFarlandFrom the Department of Neurology (J.R.W., D.S.H.), Albany Stratton Veterans Affairs Medical Center; Wadsworth Center (J.R.W., T.M.V., S.M.H., L.M.M., C.S.C., S.W., D.J.M., E.W.S.), National Center for Adaptive Neurotechnologies, New York State Department of Health, Albany; Durham Veterans Affairs Medical Center (R.S.B.) and Department of Neurology (R.S.B.), Duke University School of Medicine, NC; Veterans Affairs Cooperative Studies Program Coordinating Center (D.J.R., H.S., T.P.), Hines VA Medical Center, IL; Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center (R.J.R.) and University of New Mexico College of Pharmacy; Department of Neurology (P.G.B.), Louis Stokes Cleveland Veterans Affairs Medical Center, OH; Providence Veterans Affairs Medical Center (A.C.L.) and Department of Neurology, Brown University, RI; Veterans Affairs Connecticut Healthcare System (H.S.P.) and Department of Neurology, Yale School of Medicine, New Haven, CT; Department of Communication Science and Disorders (K.J.H.), University of Pittsburgh, PA; Cooperative Studies Program Central Office (D.G.H.), Department of Veterans Affairs Office of Research & Development, Washington, DC; and Louis Stokes Cleveland Veterans Affairs Medical Center (R.L.R.) and Department of Neurology, Case Western Reserve University School of Medicine, OH.
Eric W SellersFrom the Department of Neurology (J.R.W., D.S.H.), Albany Stratton Veterans Affairs Medical Center; Wadsworth Center (J.R.W., T.M.V., S.M.H., L.M.M., C.S.C., S.W., D.J.M., E.W.S.), National Center for Adaptive Neurotechnologies, New York State Department of Health, Albany; Durham Veterans Affairs Medical Center (R.S.B.) and Department of Neurology (R.S.B.), Duke University School of Medicine, NC; Veterans Affairs Cooperative Studies Program Coordinating Center (D.J.R., H.S., T.P.), Hines VA Medical Center, IL; Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center (R.J.R.) and University of New Mexico College of Pharmacy; Department of Neurology (P.G.B.), Louis Stokes Cleveland Veterans Affairs Medical Center, OH; Providence Veterans Affairs Medical Center (A.C.L.) and Department of Neurology, Brown University, RI; Veterans Affairs Connecticut Healthcare System (H.S.P.) and Department of Neurology, Yale School of Medicine, New Haven, CT; Department of Communication Science and Disorders (K.J.H.), University of Pittsburgh, PA; Cooperative Studies Program Central Office (D.G.H.), Department of Veterans Affairs Office of Research & Development, Washington, DC; and Louis Stokes Cleveland Veterans Affairs Medical Center (R.L.R.) and Department of Neurology, Case Western Reserve University School of Medicine, OH.
Hairong ShiFrom the Department of Neurology (J.R.W., D.S.H.), Albany Stratton Veterans Affairs Medical Center; Wadsworth Center (J.R.W., T.M.V., S.M.H., L.M.M., C.S.C., S.W., D.J.M., E.W.S.), National Center for Adaptive Neurotechnologies, New York State Department of Health, Albany; Durham Veterans Affairs Medical Center (R.S.B.) and Department of Neurology (R.S.B.), Duke University School of Medicine, NC; Veterans Affairs Cooperative Studies Program Coordinating Center (D.J.R., H.S., T.P.), Hines VA Medical Center, IL; Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center (R.J.R.) and University of New Mexico College of Pharmacy; Department of Neurology (P.G.B.), Louis Stokes Cleveland Veterans Affairs Medical Center, OH; Providence Veterans Affairs Medical Center (A.C.L.) and Department of Neurology, Brown University, RI; Veterans Affairs Connecticut Healthcare System (H.S.P.) and Department of Neurology, Yale School of Medicine, New Haven, CT; Department of Communication Science and Disorders (K.J.H.), University of Pittsburgh, PA; Cooperative Studies Program Central Office (D.G.H.), Department of Veterans Affairs Office of Research & Development, Washington, DC; and Louis Stokes Cleveland Veterans Affairs Medical Center (R.L.R.) and Department of Neurology, Case Western Reserve University School of Medicine, OH.
Tamara PaineFrom the Department of Neurology (J.R.W., D.S.H.), Albany Stratton Veterans Affairs Medical Center; Wadsworth Center (J.R.W., T.M.V., S.M.H., L.M.M., C.S.C., S.W., D.J.M., E.W.S.), National Center for Adaptive Neurotechnologies, New York State Department of Health, Albany; Durham Veterans Affairs Medical Center (R.S.B.) and Department of Neurology (R.S.B.), Duke University School of Medicine, NC; Veterans Affairs Cooperative Studies Program Coordinating Center (D.J.R., H.S., T.P.), Hines VA Medical Center, IL; Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center (R.J.R.) and University of New Mexico College of Pharmacy; Department of Neurology (P.G.B.), Louis Stokes Cleveland Veterans Affairs Medical Center, OH; Providence Veterans Affairs Medical Center (A.C.L.) and Department of Neurology, Brown University, RI; Veterans Affairs Connecticut Healthcare System (H.S.P.) and Department of Neurology, Yale School of Medicine, New Haven, CT; Department of Communication Science and Disorders (K.J.H.), University of Pittsburgh, PA; Cooperative Studies Program Central Office (D.G.H.), Department of Veterans Affairs Office of Research & Development, Washington, DC; and Louis Stokes Cleveland Veterans Affairs Medical Center (R.L.R.) and Department of Neurology, Case Western Reserve University School of Medicine, OH.
Donald S HigginsFrom the Department of Neurology (J.R.W., D.S.H.), Albany Stratton Veterans Affairs Medical Center; Wadsworth Center (J.R.W., T.M.V., S.M.H., L.M.M., C.S.C., S.W., D.J.M., E.W.S.), National Center for Adaptive Neurotechnologies, New York State Department of Health, Albany; Durham Veterans Affairs Medical Center (R.S.B.) and Department of Neurology (R.S.B.), Duke University School of Medicine, NC; Veterans Affairs Cooperative Studies Program Coordinating Center (D.J.R., H.S., T.P.), Hines VA Medical Center, IL; Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center (R.J.R.) and University of New Mexico College of Pharmacy; Department of Neurology (P.G.B.), Louis Stokes Cleveland Veterans Affairs Medical Center, OH; Providence Veterans Affairs Medical Center (A.C.L.) and Department of Neurology, Brown University, RI; Veterans Affairs Connecticut Healthcare System (H.S.P.) and Department of Neurology, Yale School of Medicine, New Haven, CT; Department of Communication Science and Disorders (K.J.H.), University of Pittsburgh, PA; Cooperative Studies Program Central Office (D.G.H.), Department of Veterans Affairs Office of Research & Development, Washington, DC; and Louis Stokes Cleveland Veterans Affairs Medical Center (R.L.R.) and Department of Neurology, Case Western Reserve University School of Medicine, OH.
Albert C LoFrom the Department of Neurology (J.R.W., D.S.H.), Albany Stratton Veterans Affairs Medical Center; Wadsworth Center (J.R.W., T.M.V., S.M.H., L.M.M., C.S.C., S.W., D.J.M., E.W.S.), National Center for Adaptive Neurotechnologies, New York State Department of Health, Albany; Durham Veterans Affairs Medical Center (R.S.B.) and Department of Neurology (R.S.B.), Duke University School of Medicine, NC; Veterans Affairs Cooperative Studies Program Coordinating Center (D.J.R., H.S., T.P.), Hines VA Medical Center, IL; Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center (R.J.R.) and University of New Mexico College of Pharmacy; Department of Neurology (P.G.B.), Louis Stokes Cleveland Veterans Affairs Medical Center, OH; Providence Veterans Affairs Medical Center (A.C.L.) and Department of Neurology, Brown University, RI; Veterans Affairs Connecticut Healthcare System (H.S.P.) and Department of Neurology, Yale School of Medicine, New Haven, CT; Department of Communication Science and Disorders (K.J.H.), University of Pittsburgh, PA; Cooperative Studies Program Central Office (D.G.H.), Department of Veterans Affairs Office of Research & Development, Washington, DC; and Louis Stokes Cleveland Veterans Affairs Medical Center (R.L.R.) and Department of Neurology, Case Western Reserve University School of Medicine, OH.
Huned S PatwaFrom the Department of Neurology (J.R.W., D.S.H.), Albany Stratton Veterans Affairs Medical Center; Wadsworth Center (J.R.W., T.M.V., S.M.H., L.M.M., C.S.C., S.W., D.J.M., E.W.S.), National Center for Adaptive Neurotechnologies, New York State Department of Health, Albany; Durham Veterans Affairs Medical Center (R.S.B.) and Department of Neurology (R.S.B.), Duke University School of Medicine, NC; Veterans Affairs Cooperative Studies Program Coordinating Center (D.J.R., H.S., T.P.), Hines VA Medical Center, IL; Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center (R.J.R.) and University of New Mexico College of Pharmacy; Department of Neurology (P.G.B.), Louis Stokes Cleveland Veterans Affairs Medical Center, OH; Providence Veterans Affairs Medical Center (A.C.L.) and Department of Neurology, Brown University, RI; Veterans Affairs Connecticut Healthcare System (H.S.P.) and Department of Neurology, Yale School of Medicine, New Haven, CT; Department of Communication Science and Disorders (K.J.H.), University of Pittsburgh, PA; Cooperative Studies Program Central Office (D.G.H.), Department of Veterans Affairs Office of Research & Development, Washington, DC; and Louis Stokes Cleveland Veterans Affairs Medical Center (R.L.R.) and Department of Neurology, Case Western Reserve University School of Medicine, OH.
Katherine J HillFrom the Department of Neurology (J.R.W., D.S.H.), Albany Stratton Veterans Affairs Medical Center; Wadsworth Center (J.R.W., T.M.V., S.M.H., L.M.M., C.S.C., S.W., D.J.M., E.W.S.), National Center for Adaptive Neurotechnologies, New York State Department of Health, Albany; Durham Veterans Affairs Medical Center (R.S.B.) and Department of Neurology (R.S.B.), Duke University School of Medicine, NC; Veterans Affairs Cooperative Studies Program Coordinating Center (D.J.R., H.S., T.P.), Hines VA Medical Center, IL; Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center (R.J.R.) and University of New Mexico College of Pharmacy; Department of Neurology (P.G.B.), Louis Stokes Cleveland Veterans Affairs Medical Center, OH; Providence Veterans Affairs Medical Center (A.C.L.) and Department of Neurology, Brown University, RI; Veterans Affairs Connecticut Healthcare System (H.S.P.) and Department of Neurology, Yale School of Medicine, New Haven, CT; Department of Communication Science and Disorders (K.J.H.), University of Pittsburgh, PA; Cooperative Studies Program Central Office (D.G.H.), Department of Veterans Affairs Office of Research & Development, Washington, DC; and Louis Stokes Cleveland Veterans Affairs Medical Center (R.L.R.) and Department of Neurology, Case Western Reserve University School of Medicine, OH.
Grant D HuangFrom the Department of Neurology (J.R.W., D.S.H.), Albany Stratton Veterans Affairs Medical Center; Wadsworth Center (J.R.W., T.M.V., S.M.H., L.M.M., C.S.C., S.W., D.J.M., E.W.S.), National Center for Adaptive Neurotechnologies, New York State Department of Health, Albany; Durham Veterans Affairs Medical Center (R.S.B.) and Department of Neurology (R.S.B.), Duke University School of Medicine, NC; Veterans Affairs Cooperative Studies Program Coordinating Center (D.J.R., H.S., T.P.), Hines VA Medical Center, IL; Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center (R.J.R.) and University of New Mexico College of Pharmacy; Department of Neurology (P.G.B.), Louis Stokes Cleveland Veterans Affairs Medical Center, OH; Providence Veterans Affairs Medical Center (A.C.L.) and Department of Neurology, Brown University, RI; Veterans Affairs Connecticut Healthcare System (H.S.P.) and Department of Neurology, Yale School of Medicine, New Haven, CT; Department of Communication Science and Disorders (K.J.H.), University of Pittsburgh, PA; Cooperative Studies Program Central Office (D.G.H.), Department of Veterans Affairs Office of Research & Development, Washington, DC; and Louis Stokes Cleveland Veterans Affairs Medical Center (R.L.R.) and Department of Neurology, Case Western Reserve University School of Medicine, OH.
Robert L RuffFrom the Department of Neurology (J.R.W., D.S.H.), Albany Stratton Veterans Affairs Medical Center; Wadsworth Center (J.R.W., T.M.V., S.M.H., L.M.M., C.S.C., S.W., D.J.M., E.W.S.), National Center for Adaptive Neurotechnologies, New York State Department of Health, Albany; Durham Veterans Affairs Medical Center (R.S.B.) and Department of Neurology (R.S.B.), Duke University School of Medicine, NC; Veterans Affairs Cooperative Studies Program Coordinating Center (D.J.R., H.S., T.P.), Hines VA Medical Center, IL; Veterans Affairs Cooperative Studies Program Clinical Research Pharmacy Coordinating Center (R.J.R.) and University of New Mexico College of Pharmacy; Department of Neurology (P.G.B.), Louis Stokes Cleveland Veterans Affairs Medical Center, OH; Providence Veterans Affairs Medical Center (A.C.L.) and Department of Neurology, Brown University, RI; Veterans Affairs Connecticut Healthcare System (H.S.P.) and Department of Neurology, Yale School of Medicine, New Haven, CT; Department of Communication Science and Disorders (K.J.H.), University of Pittsburgh, PA; Cooperative Studies Program Central Office (D.G.H.), Department of Veterans Affairs Office of Research & Development, Washington, DC; and Louis Stokes Cleveland Veterans Affairs Medical Center (R.L.R.) and Department of Neurology, Case Western Reserve University School of Medicine, OH.
Funding
Training and DisseminationP41EB018783 · NIBIB · WADSWORTH CENTER · PI Peter Brunner, Jonathan Rickel Wolpaw · 2014 to 2026
$15.4MNIBIB NIH HHS P41 EB018783
Abstract
objectiveTo assess the reliability and usefulness of an EEG-based brain-computer interface (BCI) for patients with advanced amyotrophic lateral sclerosis (ALS) who used it independently at home for up to 18 months.
methodsOf 42 patients consented, 39 (93%) met the study criteria, and 37 (88%) were assessed for use of the Wadsworth BCI. Nine (21%) could not use the BCI. Of the other 28, 27 (men, age 28-79 years) (64%) had the BCI placed in their homes, and they and their caregivers were trained to use it. Use data were collected by Internet. Periodic visits evaluated BCI benefit and burden and quality of life.
resultsOver subsequent months, 12 (29% of the original 42) left the study because of death or rapid disease progression and 6 (14%) left because of decreased interest. Fourteen (33%) completed training and used the BCI independently, mainly for communication. Technical problems were rare. Patient and caregiver ratings indicated that BCI benefit exceeded burden. Quality of life remained stable. Of those not lost to the disease, half completed the study; all but 1 patient kept the BCI for further use.
conclusionThe Wadsworth BCI home system can function reliably and usefully when operated by patients in their homes. BCIs that support communication are at present most suitable for people who are severely disabled but are otherwise in stable health. Improvements in BCI convenience and performance, including some now underway, should increase the number of people who find them useful and the extent to which they are used.
Indexed as
AdultAgedAmyotrophic Lateral SclerosisBrain-Computer InterfacesElectroencephalographyHome Care ServicesHumansMaleMiddle AgedSelf CareTherapy, Computer-AssistedUnited StatesUnited States Department of Veterans Affairs
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Registered trials
NCT06810219ClinicalTrials.gov
NCT07209943ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.