Evidence map›Paper›PMID 29950407›Full record

ArticleJournal of virology2018

Attenuated Herpes Simplex Virus 1 (HSV-1) Expressing a Mutant Form of ICP6 Stimulates a Strong Immune Response That Protects Mice against HSV-1-Induced Corneal Disease.

David J Davido, Eleain M Tu, Hong Wang, Maria Korom, Andreu Gazquez Casals, P Jahnu Reddy, Heba H Mostafa, Benjamin Combs, Steve D Haenchen, Lynda A Morrison

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

David J DavidoDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA ddavido@ku.edu lynda.morrison@health.slu.edu.
Eleain M TuDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
Hong WangDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
Maria KoromDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
Andreu Gazquez CasalsDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
P Jahnu ReddyDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
Heba H MostafaDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Benjamin CombsDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Steve D HaenchenDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Lynda A MorrisonDepartment of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, Missouri, USA ddavido@ku.edu lynda.morrison@health.slu.edu.
Saint Louis University · USUniversity of Kansas · US

Funding

Improving Vaccine Safety and Efficacy to Control Primary HSV-1 InfectionsR21EY019739 · NEI · SAINT LOUIS UNIVERSITY · PI DAVIDO, DAVID J, MORRISON, LYNDA A. · 2009 to 2010
$411k
NEI NIH HHS R21 EY019739
6 · The paper itself

Abstract

We previously isolated a herpes simplex virus 1 (HSV-1) mutant, KOS-NA, that carries two nonsynonymous mutations in

Indexed as

AnimalsChlorocebus aethiopsDisease Models, AnimalHerpes SimplexHerpesvirus 1, HumanHerpesvirus VaccinesImmediate-Early ProteinsKeratitis, HerpeticMiceMutationVaccines, AttenuatedVero CellsViral ProteinsVirus LatencyVirus Replicationherpes simplex virus type 1-protein ICP6Herpesvirus VaccinesImmediate-Early ProteinsVaccines, AttenuatedViral Proteinscorneaherpes simplex virusHSV-1ICP6immunizationkeratitismutantocularvaccine

Identifiers

PMID29950407
PMCPMC6096795
OpenAlexW2809812945

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.