Evidence map›Paper›PMID 29950344›Full record

ArticleGut2019

Impact of characteristics of organ failure and infected necrosis on mortality in necrotising pancreatitis.

Nicolien J Schepers, Olaf J Bakker, Marc G Besselink, Usama Ahmed Ali, Thomas L Bollen, Hein G Gooszen, Hjalmar C van Santvoort, Marco J Bruno, Dutch Pancreatitis Study Group

Open access · greenAbstract readComparative StudyMulticenter Study
PubMed Publisher
In one paragraph

Article in Gut, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 255 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
255citing papers in PubMed, 10 pooled it
23.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

255 citing papers in PubMed, 10 syntheses or guidelines pooled it, 482 citations in OpenAlex.

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195 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Nicolien J SchepersDepartment of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0003-1957-0399
Olaf J BakkerDepartment of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands.
Marc G BesselinkDepartment of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
Usama Ahmed AliDepartment of Surgery, University Medical Center, Utrecht, The Netherlands.
Thomas L BollenDepartment of Radiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
Hein G GooszenDepartment of Operation Rooms and Evidence Based Surgery, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Hjalmar C van SantvoortDepartment of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands.
Marco J BrunoDepartment of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Dutch Pancreatitis Study Group
St. Antonius Ziekenhuis · NLErasmus MC · NLAmsterdam UMC Location University of Amsterdam · NLRadboud University Nijmegen · NLUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIn patients with pancreatitis, early persisting organ failure is believed to be the most important cause of mortality. This study investigates the relation between the timing (onset and duration) of organ failure and mortality and its association with infected pancreatic necrosis in patients with necrotising pancreatitis.

designWe performed a post hoc analysis of a prospective database of 639 patients with necrotising pancreatitis from 21 hospitals. We evaluated the onset, duration and type of organ failure (ie, respiratory, cardiovascular and renal failure) and its association with mortality and infected pancreatic necrosis.

resultsIn total, 240 of 639 (38%) patients with necrotising pancreatitis developed organ failure. Persistent organ failure (ie, any type or combination) started in the first week in 51% of patients with 42% mortality, in 13% during the second week with 46% mortality and in 36% after the second week with 29% mortality. Mortality in patients with persistent multiple organ failure lasting <1 week, 1-2 weeks, 2-3 weeks or longer than 3 weeks was 43%, 38%, 46% and 52%, respectively (p=0.68). Mortality was higher in patients with organ failure alone than in patients with organ failure and infected pancreatic necrosis (44% vs 29%, p=0.04). However, when excluding patients with very early mortality (within 10 days of admission), patients with organ failure with or without infected pancreatic necrosis had similar mortality rates (28% vs 34%, p=0.33).

conclusionIn patients with necrotising pancreatitis, early persistent organ failure is not associated with increased mortality when compared with persistent organ failure which develops further on during the disease course. Furthermore, no association was found between the duration of organ failure and mortality.

Indexed as

Cause of DeathAdultAgedCohort StudiesDatabases, FactualDisease ProgressionFemaleFollow-Up StudiesHumansMaleMiddle AgedMultiple Organ FailurePancreatitis, Acute NecrotizingProportional Hazards ModelsProspective StudiesRisk Assessmentacute pancreatitisinflammationpancreas

Identifiers

PMID29950344
OpenAlexW2811115492

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.