Evidence map›Paper›PMID 29950338›Full record

ArticleJournal of clinical microbiology2018

Rapid Detection of Carbapenemase Production Directly from Blood Culture by Colorimetric Methods: Evaluation in a Routine Microbiology Laboratory.

Daiana de Lima-Morales, Helena Ávila, Tatiana Soldi, Tanise Vendruscolo Dalmolin, Larissa Lutz, Valério Aquino, Alexandre Prehn Zavascki, Afonso Luís Barth

Open access · bronzeAbstract readComparative StudyEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Rapid detection of carbapenemase production inJournal of clinical microbiology · 2025
    Article
  2. Rising Drug Resistance Among Gram-Negative Pathogens in Bloodstream Infections: A Multicenter Study in Ulanhot, Inner Mongolia (2017-2021).Medical science monitor : international medical journal of experimental and clinical research · 2023
    Article
  3. Article
  4. Rapid detection of carbapenemase-producing organisms directly from blood cultures positive for Gram-negative bacilli.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021
    Article
  5. Review
  6. Review
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Assessment of rapid direct E-test on positive blood culture for same-day antimicrobial susceptibility.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2019
    Article
  12. Rapid detection of carbapenemases directly from positive blood cultures by the β-CARBA test.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019
    Article
  13. Carbapenem-ResistantInternational journal of general medicine · 2019
    Review
  14. Performance Evaluation of the MBT STARFrontiers in microbiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Daiana de Lima-MoralesLABRESIS-Laboratório de Pesquisa em Resistência Bacteriana, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
Helena ÁvilaLABRESIS-Laboratório de Pesquisa em Resistência Bacteriana, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
Tatiana SoldiLABRESIS-Laboratório de Pesquisa em Resistência Bacteriana, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
Tanise Vendruscolo DalmolinLABRESIS-Laboratório de Pesquisa em Resistência Bacteriana, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
Larissa LutzHospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
Valério AquinoHospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
Alexandre Prehn ZavasckiInfectious Diseases Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
Afonso Luís BarthLABRESIS-Laboratório de Pesquisa em Resistência Bacteriana, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil albarth@hcpa.edu.br.
Hospital de Clínicas de Porto Alegre · BRUniversidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to evaluate the two rapid colorimetric methods (CNPt-Direct and Blue-Carba) for the detection of carbapenemase production directly from blood culture in a routine microbiology laboratory. The methods were initially evaluated on spiked blood cultures with 61 carbapenemase-positive isolates. Afterwards, they were used in blood cultures (314 samples were evaluated) obtained from patients in a routine microbiology laboratory during a period of 6 months. The colorimetric methods were compared to the conventional culture of blood. The results of the spiked blood cultures indicated that both colorimetric methods presented positive results for the vast majority (95%) of the isolates harboring KPC, NDM, and IMP genes. However, the assay failed to detect many GES- and OXA-48-like-positive isolates (65% positive results). In the second part of the study, a total of 314 blood cultures from patients were evaluated, and 33 yielded

Indexed as

Anti-Bacterial AgentsBacterial ProteinsBacteriological Techniquesbeta-LactamasesBlood CultureColorimetryDiagnostic Tests, RoutineDrug Resistance, BacterialEnterobacteriaceaeEnterobacteriaceae InfectionsFalse Negative ReactionsHumansMeropenemReagent Kits, DiagnosticSensitivity and SpecificityAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasescarbapenemaseMeropenemReagent Kits, Diagnosticblood culturecarbapenemasecolorimetric methodsrapid test

Identifiers

PMID29950338
PMCPMC6113463
OpenAlexW2811060829

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.