ArticleJournal of neurodevelopmental disorders2018
Visual subcircuit-specific dysfunction and input-specific mispatterning in the superior colliculus of fragile X mice.
Article in Journal of neurodevelopmental disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Electroretinography biomarkers indicate disrupted visual processing in Fragile X syndrome.Journal of neurodevelopmental disorders · 2026Article
- Connectivity, Computation, and Plasticity of the Early Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- The Superior Colliculus: Cell Types, Connectivity, and Behavior.Neuroscience bulletin · 2022Review
- Review
- Diverse modes of binocular interactions in the mouse superior colliculus.Journal of neurophysiology · 2022Article
- Superior Colliculus to VTA pathway controls orienting response and influences social interaction in mice.Nature communications · 2022Article
- Wiring subcortical image-forming centers: Topography, laminar targeting, and map alignment.Current topics in developmental biology · 2021Review
- Reduced axonal caliber and structural changes in a rat model of Fragile X syndrome with a deletion of a K-Homology domain of Fmr1.Translational psychiatry · 2020Article
- Cellular localization of the FMRP in rat retina.Bioscience reports · 2020Article
- A Chrnb3-Cre BAC transgenic mouse line for manipulation of gene expression in retinal ganglion cells.Genesis (New York, N.Y. : 2000) · 2019Article
- Visual Behavior Impairments as an Aberrant Sensory Processing in the Mouse Model of Fragile X Syndrome.Frontiers in behavioral neuroscience · 2019Article
- Impaired Attention Orienting in Young Children With Fragile X Syndrome.Frontiers in psychology · 2019Article
- Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundSensory processing deficits are frequently co-morbid with neurodevelopmental disorders. For example, patients with fragile X syndrome (FXS), caused by a silencing of the FMR1 gene, exhibit impairments in visual function specific to the dorsal system, which processes motion information. However, the developmental and circuit mechanisms underlying this deficit remain unclear. Recently, the superior colliculus (SC), a midbrain structure regulating head and eye movements, has emerged as a model for dissecting visual circuit development and function. Previous studies have demonstrated a critical role for activity-dependent processes in the development of visual circuitry in the SC. Based on the known role of the FMR1 gene product in activity-dependent synaptic plasticity, we explored the function and organization of visual circuits in the SC of a mouse model of FXS (Fmr1
methodsWe utilized in vivo extracellular electrophysiology in combination with computer-controlled visual stimuli to determine the receptive field properties of visual neurons in the SC of control and Fmr1
resultsReceptive fields of visual neurons in the SC of Fmr1
conclusionsFmr1 is required for the proper development of visual circuit organization and function in the SC. We find that visual dysfunction is heterogeneously manifested in a subcircuit-specific manner in Fmr1
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