Evidence map›Paper›PMID 29950132›Full record

ArticleAutophagy2018

Role of the MAPK/cJun NH

Seda Avcioglu Barutcu, Nomeda Girnius, Santiago Vernia, Roger J Davis

Open access · hybridAbstract read
In one paragraph

Article in Autophagy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Cells · 2024
    Review
  9. Article
  10. Inflammation Causes Exacerbation of COVID-19: How about Skin Inflammation?International journal of molecular sciences · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2020
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Seda Avcioglu Barutcua Program in Molecular Medicine , University of Massachusetts Medical School , Worcester , MA , USA.ORCID 0000-0003-2739-4153
Nomeda Girniusa Program in Molecular Medicine , University of Massachusetts Medical School , Worcester , MA , USA.ORCID 0000-0002-7267-5950
Santiago Verniaa Program in Molecular Medicine , University of Massachusetts Medical School , Worcester , MA , USA.ORCID 0000-0001-6728-5555
Roger J Davisa Program in Molecular Medicine , University of Massachusetts Medical School , Worcester , MA , USA.ORCID 0000-0002-0130-1652
University of Massachusetts Chan Medical School · USHoward Hughes Medical Institute · US

Funding

Adipose Tissue Metabolic Stress ResponsesR01DK112698 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2017 to 2025
$4.4M
Metabolic Stress SignalingR01DK107220 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2016 to 2023
$3.6M
Howard Hughes Medical InstituteMedical Research Council MC_UP_1102/18NIDDK NIH HHS R01 DK107220NIDDK NIH HHS R01 DK112698
6 · The paper itself

Abstract

Autophagy is required for cellular homeostasis and can determine cell viability in response to stress. It is established that MTOR is a master regulator of starvation-induced macroautophagy/autophagy, but recent studies have also implicated an essential role for the MAPK8/cJun NH ABBREVIATIONS: AKT: thymoma viral proto-oncogene;ALB: albumin; ATG4: autophagy related 4; BCL2: B cell leukemia/lymphoma 2; BECN1: beclin 1, autophagy related; BNIP3: BCL2/adenovirus E1B interacting protein 3; CQ: chloroquine diphosphate; DMEM: Dulbecco's modified Eagle's medium; EDTA: ethylenediaminetetraacetic acid; EBSS: Earle's balanced salt solution; FBS: fetal bovine serum; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HRAS: Harvey rat sarcoma virus oncogene; IgG: Immunoglobulin G; MAPK3/ERK1: mitogen-activated protein kinase 3; MAPK8/JNK1: mitogen-activated protein kinase 8; MAPK9/JNK2: mitogen-activated protein kinase 9; MAPK10/JNK3: mitogen-activated protein kinase 10; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MEFs: mouse embryonic fibroblasts; MTOR: mechanistic target of rapamycin kinase; RPS6KB1/p70: ribosomal protein S6 kinase, polypeptide 1; PPARA: peroxisome proliferator activated receptor alpha; SEM: standard error of the mean; SQSTM1/p62: sequestosome 1; TORC1: target of rapamycin complex 1; TORC2: target of rapamycin complex 2; TRP53: transforming related protein 53; TUBA: tubulin alpha; UV: ultraviolet; WT: wild-type.

Indexed as

AutophagyMAP Kinase Signaling SystemAmino AcidsAnimalsCell HypoxiaCells, CulturedEnzyme ActivationEpithelial CellsHepatocytesMiceMitogen-Activated Protein Kinase 8Mitogen-Activated Protein Kinase 9Naphthyridinesras ProteinsTOR Serine-Threonine Kinases1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-oneAmino AcidsMitogen-Activated Protein Kinase 8Mitogen-Activated Protein Kinase 9Naphthyridinesras ProteinsTOR Serine-Threonine KinasesEpithelial cellfibroblasthepatocyteMAPK8MAPK9MTOR

Identifiers

PMID29950132
PMCPMC6135577
OpenAlexW2810911894

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.