Evidence map›Paper›PMID 29949407›Full record

Trial reportAmerican journal of physiology. Regulatory, integrative and comparative physiology2018

Alterations in dietary sodium intake affect cardiovagal baroreflex sensitivity.

Matthew C Babcock, Michael S Brian, Joseph C Watso, David G Edwards, Sean D Stocker, Megan M Wenner, William B Farquhar

Open access · bronzeAbstract readComparative StudyRandomized Controlled Trial
In one paragraph

Trial report in American journal of physiology. Regulatory, integrative and comparative physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Sugar-sweetened soft drink consumption acutely decreases spontaneous baroreflex sensitivity and heart rate variability.American journal of physiology. Regulatory, integrative and comparative physiology · 2021
    Trial
  5. Trial
  6. Trial
  7. Salt Loading Blunts Central and Peripheral Postexercise Hypotension.Medicine and science in sports and exercise · 2020
    Trial
  8. Short-term water deprivation does not increase blood pressure variability or impair neurovascular function in healthy young adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2020
    Trial
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. The Influence of Dietary Salt Beyond Blood Pressure.Current hypertension reports · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Matthew C BabcockDepartment of Kinesiology and Applied Physiology, University of Delaware , Newark, Delaware.ORCID 0000-0002-8047-4411
Michael S BrianDepartment of Kinesiology and Applied Physiology, University of Delaware , Newark, Delaware.
Joseph C WatsoDepartment of Kinesiology and Applied Physiology, University of Delaware , Newark, Delaware.ORCID 0000-0001-7840-0643
David G EdwardsDepartment of Kinesiology and Applied Physiology, University of Delaware , Newark, Delaware.
Sean D StockerDepartment of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania.
Megan M WennerDepartment of Kinesiology and Applied Physiology, University of Delaware , Newark, Delaware.ORCID 0000-0003-0055-783X
William B FarquharDepartment of Kinesiology and Applied Physiology, University of Delaware , Newark, Delaware.
University of Delaware · USUniversity of Pittsburgh · US

Funding

VASCULAR EFFECTS OF DIETARY SALT IN HUMANS WITH SALT-RESISTANT BPR01HL104106 · NHLBI · UNIVERSITY OF DELAWARE · PI EDWARDS, DAVID G, FARQUHAR, WILLIAM B · 2011 to 2021
$4.5M
Adverse Neurogenic Actions of Dietary SaltR01HL128388 · NHLBI · UNIVERSITY OF DELAWARE · PI FARQUHAR, WILLIAM B, STOCKER, SEAN D · 2016 to 2019
$2.6M
NHLBI NIH HHS R01 HL104106NHLBI NIH HHS R01 HL128388
6 · The paper itself

Abstract

High dietary sodium intake has been linked to alterations in neurally mediated cardiovascular function, but the effects of high sodium on cardiovagal baroreflex sensitivity (cBRS) in healthy adults are unknown. The purpose of this study was to determine whether high dietary sodium alters cBRS and heart rate variability (HRV) and whether acute intravenous sodium loading similarly alters cBRS and HRV. High dietary sodium (300 mmol/day, 7 days) was compared with low dietary sodium (20 mmol/day, 7 days; randomized) in 14 participants (38 ± 4 yr old, 23 ± 1 kg/m

Indexed as

BaroreflexDiet, Sodium-RestrictedAdultBlood PressureFemaleHeartHeart RateHumansInfusions, IntravenousMaleOsmolar ConcentrationPressoreceptorsSaline Solution, HypertonicSodium Chloride, DietaryTime FactorsVagus NerveSaline Solution, HypertonicSodium Chloride, Dietarybaroreflex sensitivitycardiovagalheart rate variabilityhigh-salt diethypertonic salineplasma osmolalitysequence methodserum sodium

Identifiers

PMID29949407
PMCPMC6230891
OpenAlexW2811331607

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.