Evidence map›Paper›PMID 29949339›Full record

ArticleACS applied materials & interfaces2018

Increasing the Resistance of Living Cells against Oxidative Stress by Nonnatural Surfactants as Membrane Guards.

Marius Kunkel, Stefan Schildknecht, Klaus Boldt, Lukas Zeyffert, David Schleheck, Marcel Leist, Sebastian Polarz

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Marius KunkelUniversity of Konstanz , Universitätsstrasse 10 , 78457 Konstanz , Germany.
Stefan SchildknechtUniversity of Konstanz , Universitätsstrasse 10 , 78457 Konstanz , Germany.
Klaus BoldtUniversity of Konstanz , Universitätsstrasse 10 , 78457 Konstanz , Germany.ORCID http://orcid.org/0000-0002-0035-2490
Lukas ZeyffertUniversity of Konstanz , Universitätsstrasse 10 , 78457 Konstanz , Germany.
David SchleheckUniversity of Konstanz , Universitätsstrasse 10 , 78457 Konstanz , Germany.
Marcel LeistUniversity of Konstanz , Universitätsstrasse 10 , 78457 Konstanz , Germany.
Sebastian PolarzUniversity of Konstanz , Universitätsstrasse 10 , 78457 Konstanz , Germany.ORCID http://orcid.org/0000-0003-1651-4906
University of Konstanz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The importation of construction principles or even constituents from biology into materials science is a prevailing concept. Vice versa, the cellular level modification of living systems with nonnatural components is much more difficult to achieve. It has been done for analytical purposes, for example, imaging, to learn something about intracellular processes. Cases describing the improvement of a biological function by the integration of a nonnatural (nano)constituent are extremely rare. Because biological membranes contain some kind of a surfactant, for example, phospholipids, our idea is to modify cells with a newly synthesized surfactant. However, this surfactant is intended to possess an additional functionality, which is the reduction of oxidative stress. We report the synthesis of a surfactant with Janus-type head group architecture, a fullerene C

Indexed as

Oxidative StressAntioxidantsCell LineHumansReactive Oxygen SpeciesSuperoxidesSurface-Active AgentsAntioxidantsReactive Oxygen SpeciesSuperoxidesSurface-Active Agentsamphiphilefullerenefullerenolliving cellsmembraneROS quenchingsuperoxidesurfactant

Identifiers

PMID29949339
PMCPMC6091502
OpenAlexW2810898773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.