Evidence map›Paper›PMID 29949322›Full record

ArticleJBRA assisted reproduction2018

Are age and anti-Müllerian hormone good predictors of ovarian reserve and response in women undergoing IVF?

Juliano Augusto Brum Scheffer, Bruno Scheffer, Rafaela Scheffer, Fabio Florencio, Michael Grynberg, Daniel Mendez Lozano

Open access · greenAbstract read
In one paragraph

Article in JBRA assisted reproduction, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 34 citations in OpenAlex.

  1. Ambient PMEnvironmental epidemiology (Philadelphia, Pa.) · 2026
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  13. Predictive Factors for Live Birth in FreshFrontiers in endocrinology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Juliano Augusto Brum SchefferIBRRA - Brazilian Institute of Assisted Reproduction, Belo Horizonte, Brazil.
Bruno SchefferIBRRA - Brazilian Institute of Assisted Reproduction, Belo Horizonte, Brazil.
Rafaela SchefferIBRRA - Brazilian Institute of Assisted Reproduction, Belo Horizonte, Brazil.
Fabio FlorencioIBRRA - Brazilian Institute of Assisted Reproduction, Belo Horizonte, Brazil.
Michael GrynbergDepartment of Reproductive Medicine, Hôpital Jean Verdier (AP-HP), University Paris XIII, and INSERM, Paris, France.
Daniel Mendez LozanoSchool of Medicine, Tecnologico de Monterrey and Center for Reproductive Medicine CREASIS, San Pedro Monterrey, Mexico.
Tecnológico de Monterrey · MXUnit of Functional and Adaptive Biology · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOvarian reserve evaluation has been the focus of substantial clinical research for several years. This study aimed to examine the associations between markers of ovarian reserve and ovarian response.

methodsThis prospective study included 132 infertile women aged 24-48 years undergoing routine exploration during unstimulated cycles prior to the start of assisted reproductive technology (ART) treatments at our center from July 2015 to January 2017. Descriptive parameters and patient characteristics were reported as mean (SD) or median (range) values depending on the data distribution pattern. Student's t-test was performed for continuous variables; the Wilcoxon and Pearson's test were used for data not following a normal distribution; and Fisher's test was used for categorical variables. p<0.05 was considered statistically significant.

resultsAt the time of the study, the patients had a mean age of 35.7±3.84 years. On day 3 of the cycle, the mean anti-Müllerian hormone (AMH) serum level was 2.84±1.57 ng/mL and the patients had 14.68±4.2 antral follicles (AFC). A significant correlation was observed between AMH and age (r=-0.34 p<.01), follicle stimulating hormone (FSH) serum levels (r=-0.32, p<.01), AFC (r=0.81, p<.00001), total dose of medication during ovarian stimulation (r=-0.28, p<.0003), and ongoing pregnancy rate (p<.05). Age was significantly correlated with FSH (r=0.46, p<.01), AFC (r=-0.34, p<.00001), total dose of medication during ovarian stimulation (r=0.43, p<.0003), and ongoing pregnancy rate (p<.04).

conclusionSerum AMH and age are independent predictors of ovarian reserve and ovarian stimulation outcome in infertile women. Age and serum AMH level may be used to advise subfertile couples of their pregnancy prospects.

Indexed as

AdultAge FactorsAnti-Mullerian HormoneFemaleFertilization in VitroHumansInfertility, FemaleMiddle AgedOvarian ReserveOvulation InductionPregnancyPrognosisProspective StudiesTreatment OutcomeYoung AdultAnti-Mullerian HormoneAgeanti-Müllerian hormoneantral follicle countongoing pregnancy

Identifiers

PMID29949322
PMCPMC6106624
OpenAlexW2885674119

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.