Evidence map›Paper›PMID 29949068›Full record

ArticleJournal of community genetics2019

Genetic counseling in an indigenous Filipino community with a high prevalence of A2ML1-related otitis media.

Eva Maria Cutiongco-de la Paz, Melquiadesa Pedro, Talitha Karisse L Yarza, Sheryl Mae Lagrana-Villagracia, Abegail Jayne P Amoranto, Edbert Jasper M Jover, Ma Theresa B Domine, Charlotte M Chiong, Regie Lyn P Santos-Cortez

Open access · bronzeAbstract read
In one paragraph

Article in Journal of community genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Exploring Genetic Counselors' Experiences with Indigenous Patient Populations.Journal of racial and ethnic health disparities · 2025
    Article
  2. Audiologic Measures in an Indigenous Community withGenetic testing and molecular biomarkers · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Eva Maria Cutiongco-de la PazUniversity of the Philippines (UP) Manila - National Institutes of Health (NIH), Pedro Gil St., 1000, Manila, Philippines.
Melquiadesa PedroPhilippine National Ear Institute, UP Manila - NIH, Manila, Philippines.
Talitha Karisse L YarzaPhilippine National Ear Institute, UP Manila - NIH, Manila, Philippines.
Sheryl Mae Lagrana-VillagraciaPhilippine National Ear Institute, UP Manila - NIH, Manila, Philippines.
Abegail Jayne P AmorantoInstitute of Human Genetics, UP Manila - NIH, Manila, Philippines.
Edbert Jasper M JoverInstitute of Human Genetics, UP Manila - NIH, Manila, Philippines.
Ma Theresa B DomineInstitute of Human Genetics, UP Manila - NIH, Manila, Philippines.
Charlotte M ChiongPhilippine National Ear Institute, UP Manila - NIH, Manila, Philippines.
Regie Lyn P Santos-CortezPhilippine National Ear Institute, UP Manila - NIH, Manila, Philippines. regie.santos-cortez@ucdenver.edu.
National Veterinary Institute · ETUniversity of the Philippines Manila · PHUniversity of Colorado Denver · US

Funding

Otitis Media Susceptibility and Middle Ear Microbial Shifts due to Gene VariantsR01DC015004 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI SANTOS-CORTEZ, REGIE LYN PASTOR · 2016 to 2020
$1.9M
National Institute on Deafness and Other Communication Disorders R01 DC015004NIDCD NIH HHS R01 DC015004Philippine Council for Health Research and Development - Department of Science and Technology Balik-Scientist
6 · The paper itself

Abstract

In this report, we describe the knowledge and beliefs on causes and management of otitis media of an indigenous Filipino community with a high prevalence of otitis media that is associated with an A2ML1 variant. Community lectures and individual genetic counseling were provided as intervention. Knowledge, beliefs, and health care-seeking behavior pertaining to otitis media were assessed pre- and post-genetic counseling. Twenty-five heads of households were interviewed. Beliefs regarding etiology of ear discharge varied widely, with swimming in the sea as the most commonly cited cause of ear discharge. During the post-counseling session, poor personal hygiene, dirty environment, and familial inheritance were mentioned as risk factors for otitis media or ear discharge. Knowledge about the genotypes for the A2ML1 variant and otitis media diagnoses within the household influenced beliefs on the role of hygiene and genetic susceptibility to otitis media and attitudes towards health care-seeking behavior. Genetic counseling was associated with variable improvement in knowledge on otitis media and in their understanding of genetic susceptibility to otitis media due to the A2ML1 variant. Language barriers, literacy level, cultural factors, and the complex nature of genetic information made genetic counseling in the particular population a challenge. Insights drawn from this experience recommend follow-up visits in the community.

Indexed as

A2ML1FilipinoGenetic counselingIndigenous communityOtitis media

Identifiers

PMID29949068
PMCPMC6325045
OpenAlexW2807816447

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.