Evidence map›Paper›PMID 29949063›Full record

ArticleThe journal of physiological sciences : JPS2019

Mechanism of luminal ATP activated chloride secretion in a polarized epithelium.

N Keating, K Dev, A C Hynes, L R Quinlan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physiological sciences : JPS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

N KeatingPhysiology, School of Medicine, National University of Ireland, Galway, University Road, Galway, Ireland.
K DevPhysiology, School of Medicine, National University of Ireland, Galway, University Road, Galway, Ireland.
A C HynesPhysiology, School of Medicine, National University of Ireland, Galway, University Road, Galway, Ireland.
L R QuinlanPhysiology, School of Medicine, National University of Ireland, Galway, University Road, Galway, Ireland. leo.quinlan@nuigalway.ie.
Ollscoil na Gaillimhe – University of Galway · IEUniversity Hospital Galway · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are both secretory and absorptive pathways working in tandem to support ionic movement driving fluid secretion across epithelia. The mechanisms exerting control of fluid secretion in the oviduct is yet to be fully determined. This study explored the role of apical or luminal extracellular ATP (ATPe)-stimulated ion transport in an oviduct epithelium model, using the Ussing chamber short-circuit current (Isc) technique. Basal Isc in oviduct epithelium in response to apical ATPe comprises both chloride secretion and sodium absorption and has distinct temporal phases. A rapid transient peak followed by a sustained small increase above baseline. Both phases of the apical ATPe Isc response are sensitive to anion (HCO

Indexed as

AdenosineAdenosine TriphosphateAnimalsCalciumCattleChloride ChannelsChloridesColforsinEpitheliumFemaleIon TransportOviductsAdenosineAdenosine TriphosphateCalciumChloride ChannelsChloridesColforsinATPCalcium signalingChloride channelsChloride secretionOviduct epitheliumPotassium channelsPurinoceptors

Identifiers

PMID29949063
PMCPMC10717936
OpenAlexW2807964613

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.